McGowan Institute for Regenerative Medicine

Regerative Medicine Podcasts The McGowan Institute sponsors a bi-weekly podcast on regenerative medicine. Listen to some of the world's leading regenerative medicine researchers and physicians talk about their work.

September 16, 2009 – Dr. Robert Bowser is the Director of the ALS Research for the Pittsburgh Institute for Neurodegenerative Diseases and at the Center for ALS Research at the University of Pittsburgh. He is also the Director of the ALS Tissue Bank where he helps to create the largest such tissue repository in the country. Dr. Bowser discusses the state of neurodegenerative diseases, such as ALS and Alzheimer’s, as well as the unique challenges they present to researchers.

August 27, 2009 – Major General Gale Pollock is the executive director of the Louis J. Fox Center for Vision Restoration, a division of the UPMC Eye Center. Major General Pollock is with Corporal Mike Jernigan, a medically retired marine who lost both eyes in Iraq. They discuss the BrainPort vision system, which is currently being used by Corporal Jernigan, as well as its future.

August 20, 2009 – Dr. Bryan Tillman is an assistant professor in the Division of Vascular Surgery at the University of Pittsburgh Medicine Center as well as a practicing clinician. Dr. Tillman discusses the applications of tissue engineering to construct replacement vessels for patients with peripheral vascular disease.

July 24, 2009 – Mr. Patrick Cantini, Director of Scientific Collaborations at the McGowan Institute’s Center for Industry Relations, discusses the importance and the process of establishing partnerships between the McGowan Institute and commercial enterprises and how this aids the transition from the laboratory studies to medical practice.

July 16, 2009 – Robert Kormos, MD, Director of the Artificial Heart Program, and Co-Director of Heart Transplantation at the University of Pittsburgh Medical Center, is with a former patient, Erika Haas. They discuss Erika’s experience with a Ventricular Assist Device (VAD) and how it was used as a bridge to recovery.

May 26, 2009 – Drs. Simon Watkins and Donna Beer Stolz discuss the many resources available at the Center for Biologic Imaging and the work that is done there.  Dr. Watkins is the Founder and Director of the Center for Biologic Imaging at the University of Pittsburgh, and Dr. Stolz is the Assistant Director at the Center.

April 22, 2009 – Eric Beckman, PhD, is a professor of chemical engineering at the University of Pittsburgh and the co-founder of Cohera Medical, Inc.  Dr. Beckman discusses the technology that is being developed at Cohera Medical, Inc. as well as the difficulties faced when starting a small company.

March 31, 2009 - Peter Wearden, MD, PhD, is an Assistant Professor, Pediatric Cardiac Surgery; Director Pediatric Mechanical Cardiopulmonary Support at the UPMC Children's Hospital of Pittsburgh; and a faculty member at the McGowan Institute for Regenerative Medicine.  Joining Dr. Wearden is Dr. Joel Gradowski and Cindy Gradowski, who together discuss their son’s recent cardiac treatment and recovery through the use of a ventricular assist device.

January 23, 2009 – Major General (ret.) Gale S. Pollock is the executive director of the nation’s first Center for Ocular Regeneration and Vision Restoration (CORVR), a division of the UPMC eye center.  Major General Pollock discusses her goals for CORVR as well as current studies being done to improve quality of life for those with eye injuries and blindness.

January 2, 2009 - Sanjeev G. Shroff, PhD,  is the Associate Chair of the Department of Bioengineering at the University of Pittsburgh; Professor and Gerald McGinnis Chair in Bioengineering; Professor of Medicine; and Senior Investigator, Magee-Women’s Research Institute.  Dr. Shroff shares highlights of his scientific studies on vascular stiffness and cardiovascular function as well as large-scale mathematical simulations of biological systems for research, education, and engineering design.

December 2, 2008 - Dr. David Whitcomb, Professor of Medicine, Cell Biology and Physiology, and Human Genetics at the University of Pittsburgh, discusses research that is pioneering alternative diagnosis and treatment for disorders of the pancreas, liver, and the intestine. Dr. Whitcomb is also the Chief of the Division of Gastroenterology, Hepatology, and Nutrition, as well as the founder and Director of the Center for Genomic Sciences.

November 20, 2008 - Dr. Vera Donnenberg is an Assistant Professor of Surgery and Pharmaceutical Science at the University of Pittsburgh.  Dr. Donnenberg’s research focuses on the persistent problem in cancer treatment which is cancer recurrence after an apparently successful therapy.  Cancer recurrence is mediated by a dormant and protected cancer stem/progenitor like cell. Her lab is focused on approaches that can be translated into and understanding the biologic basis for treatment failure and identifying new immunological therapeutic targets.  She introduces the concept of a cancer vaccine to address these needs.

September 15, 2008 - Dr. Steven Little is an Assistant Professor and Bicentennial Alumni Faculty Fellow, Departments of Chemical Engineering, Bioengineering, Immunology, and Medicine at the University of Pittsburgh.  Dr. Little’s focus is on the delivery of genetic vaccines with special emphasis on non-viral, particulate formulations. His current interests include controlled delivery for tissue engineering, immunotherapeutics, and biomimetic materials.

September 4, 2008 - Dr. Newell Washburn is an Assistant Professor in the Departments of Chemistry and Biomedical Engineering at Carnegie Mellon University. His primary research interests include wound healing and bone tissue engineering though the use of biomaterials.  Dr. Washburn discusses his current studies and shares his vision on the application of emerging technologies in these areas for clinical applications.

July 29, 2008 - Dr. Joel Schuman is the Eye and Ear Foundation Professor and Chairman of Department of Ophthalmology and the director of the UPMC Eye Center.  Dr. Schuman is considered to be one of the nation’s leading authorities on the treatment of glaucoma.  He discusses diagnostic imaging and describes a new initiative via the Center for Ocular Regeneration and Vision Restoration.

June 6, 2008 - Dr. Joerg Gerlach discusses his work on the development of tools such as bioreactors for the expansion of cells so that sufficient cells are available for cell-based therapies.  Areas of focus include the pancreas and the liver. He also explores the development of “cell factories” for the production of cells from a patient’s bone marrow.  Another of Dr. Gerlach’s interests is cell-based burn therapy, which he describes.
April 29, 2008 -- Dr. Kacey Marra discusses her research focused on the use of adipose-derived stem cells for the regeneration of nerve, bone, adipose, and cartilage. The lab uses adipose-derived stem cells for these bioengineering applications.  Also, Dr. Marra discusses her strong commitment to mentoring women and minorities in the career opportunities that are available in science and medicine.
March 24, 2008 --  Mr. Steve Winowich, Director of Clinical Bioengineering with the Artificial Heart Program at the University of Pittsburgh Medical Center (UPMC), describes a unique partnership between the clinical staff and a team of bioengineers and nurses who are a key component of a very successful program that provides mechanical circulatory support to patients that are waiting for a heart transplant. Supplemental circulatory support has been traditionally used as a bridge to a transplant, but there are also cases where the circulatory support has also been used as a bridge to recovery.
February 15, 2008 -- Dr. Phil Campbell’s research is focused on the development of “tool sets” that will be resources for regenerative medicine research and clinical therapies.  In the podcast he discusses his work on methodologies and systems that will be required for cell expansion on a commercial vs. a research basis, and how his research is addressing those needs.  He also shares some insight into the use of inkjet printing technologies to print tissue engineered constructs using “bio-inks” vs. the traditional inks used in such printers.  These tool sets are proving to be a significant resource in the study of cell growth on tissue engineered constructs.  Finally, Dr. Campbell discusses his strong commitment to science-based education: from elementary students to senior citizens.
February 1, 2008 - Dr. Alan Wells discusses his pioneering studies on tumor biology and wound healing. He shares insight into the basic science and to future clinical applications of his research. One of his interests is in the development of custom therapies, patient-by-patient, for certain illnesses, such as cancer.
January 10, 2008 - Dr. Eric Lagasse discusses his pioneering research on the use of stem cells for liver therapy.  He also describes his research on the identification of cancer stem cells, and possible alternative cancer therapies if the hypothesis is affirmed that cancer stem cells are the source of the tumors and the reason for metastasis.
December 24, 2007 - Dr. Peter Wearden discusses his pioneering clinical initiatives in pediatric cardiac care as well as his collaborative research in the development and assessment of pediatric mechanical circulatory support systems. He also shares his vision for the future with new procedures that could dramatically affect the treatments for children with cardiac afflictions.
November 27, 2007 - Dr. Jennifer Ogilvie discusses her clinical focus, endocrine surgery, and her current regenerative medicine research interests that focus on the development of tissue-engineered endocrine organs, in particular bioengineered parathyroid and adrenal glands. Also, her initial studies on the development of a tumor vaccine and her strong commitment to student mentoring are discussed. 
October 17, 2007 - Dr. David Vorp discusses the assessment of mechanical factors in the genesis and progression of vascular diseases such as arterial aneurysms, atherosclerosis, vascular graft failure, and the development of tissue-engineered blood vessels. He also describes some new initiatives, such as the use of tissue engineering to treat urethral dysfunction.
August 1, 2007 - Dr. Alejandro Nieponice discusses the Clinical Translation Unit within the operative room at the Austral University Hospital, providing full cell culture capabilities to facilitate clinical translation of cell-based technologies.
June 3, 2007 - Dr. Michael Sacks discusses his work on the characterization of cardiac tissue and the various alternatives—now and in the future—for the repair of heart valves.
May 18, 2007 - Dr. Bruno Peault discusses the status of his emerging results on the identification, characterization, and application of adult stem cells for therapeutic applications.
April 30, 2007 - Dr. Rory Cooper shares highlights of his exciting studies on rehabilitation.
March 27, 2007 - Dr. Stephen Badylak explains current tissue engineering efforts to regenerate a diseased or damaged esophagus and technology that may lead to the regeneration of damaged or severed digits or limbs.
February 13, 2007 - Dr. Michael Chancellor discusses an alternative approach to the treatment of adult urinary incontinence.
Heart Health -October 27, 2006 - Dr. William Wagner reviews research on a tissue-engineered cardiac patch.
October 11, 2006 - Dr. Robert Kormos provides an overview of the evolution of the UPMC Artificial Heart Program.
September 29, 2006 - Dr. Harvey Borovetz talks about the progress made with today's ventricular assist devices.