UPMC Stroke Institute

Stroke Overview

Stroke is the leading cause of adult disability in the United States. Through advances in medical care, more people than ever before survive a stroke.

A stroke most often occurs when blood flow to the brain becomes blocked (called ischemic stroke). One of the following problems may cause this blockage:

  • a build-up of fatty substances (atherosclerotic plaque) along an artery's inner lining causes it to narrow, reduces its elasticity, and decreases its blood flow
  • a clot forms in an artery supplying the brain
  • a clot forms somewhere in the body (often the heart) and breaks free, traveling to and becoming lodged in an artery supplying the brain

A stroke may also occur if a blood vessel breaks and bleeds into or around the brain. If this happens, it is called a hemorrhagic stroke.

Risk Factors

A risk factor is something that increases your chance of getting a disease or condition.

Modifiable risk factors:

  • high blood pressure
  • narrowing of arteries supplying the brain due to atherosclerosis
  • high cholesterol levels, particularly LDL (low-density lipoprotein) cholesterol
  • smoking
  • obesity
  • lack of exercise
  • drinking excessive amounts of alcohol
  • diabetes mellitus
  • atrial fibrillation (abnormality of heart rhythm) that is treatable

Non-modifiable risk factors:

  • a prior stroke or pre-existing cardiovascular disease other than stroke
  • a prior transient ischemic attack (a temporary interrupting of the brain's blood supply, often called a mini-stroke)
  • age: 60 or older
  • family members who have had a stroke
  • race: African-American

Some patients experience a "warning stroke" or transient ischemic attack (TIA). These are symptoms of a stroke that resolve completely, usually within hours. Such patients are at a significantly increased risk of having a full-blown stroke sometime in the near future.