Basic Research on Liver Cancer
At the UPMC Liver Cancer Center, many physicians and scientists are working actively on liver cancer research.
Dr. Geller and his research laboratory are studying the molecular mechanisms responsible for apoptosis (programmed cell death) of liver cancer cells. They are trying to determine whether some of our own cellular mediators (nitric oxide) can be used to destroy established liver tumor cells. Dr. Geller also is testing a novel noninvasive radiowave machine to destroy cancer cells.
Dr. Marsh and his research colleagues are genotyping primary liver tumors (HCC) to identify molecular markers that will help us predict which cancers are likely to recur following liver transplantation or resection.
Dr. Gamblin has funding to investigate unique tumor models for liver cancer. He works with stem-cell scientists attempting to discover novel aspects of liver cancer stem cells. This work could lead to exciting drug development and tumor modeling. He also works with pharmacologists to evaluate the effects of liver cancer on drug metabolism. Dr. Gamblin collaborates with multiple scientists at the Hillman Cancer Center and the McGowan Institute for Regenerative Medicine in an effort to translate basic research efforts to potential clinical applications. Other research efforts are focused on the cellular effects of regional liver cancer treatments.