UPMC Liver Cancer Center

Percutaneous Liver Biopsy

A percutaneous liver biopsy is a procedure designed to remove a sample of liver tissue for diagnostic purposes. The procedure involves the insertion of a hollow tube needle through the skin into the liver to remove a small piece of tissue. A pathologist then looks at the tissue under a microscope and may perform special tests or stains on the tissue to detect disorders of the liver.

Before your test, you will obtain specific information from your doctor and/or nurse coordinator concerning medications you may or may not take, diet, date, time and location of your biopsy. A blood test to determine how your blood is clotting is required prior to the test.

The percutaneous liver biopsy is performed in the radiology department at UPMC with use of ultrasound. The radiologist will explain the procedure, including the benefits and risks, and will answer any questions concerning the procedure. You will sign a consent form. The ultrasound probe is moved over the liver area to locate the best area for insertion of the biopsy needle. If you have a liver mass, the tissue will be taken from that area of the liver.

A local anesthetic is injected into the skin and abdominal wall prior to the biopsy, making the procedure relatively painless. Some pressure may be felt in the liver area when the needle is inserted. Following the procedure, a small dressing is placed over the area and you will be asked to lay on your right side for several hours. This produces pressure on the liver, which may help stop any bleeding from the biopsy site. You will be able to return home the same day.

Your doctor will notify you of the results of your percutaneous liver biopsy approximately one week after the test.