The brain receives its blood supply from two sets of arteries.
The carotid arteries travel up the front of the neck and supply blood to the front part of the brain where important functions are located, including:
The vertebral arteries run through the spine and supply blood to the back of the brain (brainstem and cerebellum).
When any of these arteries are narrowed or blocked, it creates a condition called stenosis that drastically increases the risk of stroke, aneurysm, and other neurovascular disorders
Extracranial vascular disease refers to carotid or vertebral stenosis outside the skull.
Intracranial vascular disease involves the arteries within the skull or at the base of the skull.
Atherosclerosis, the hardening and narrowing of the walls of these vessels due to deposits of fats that form plaques within the arteries, is the most common cause of extracranial and intracranial vascular disease. As the plaque deposits gradually enlarge, they interfere with blood flow.
Atherosclerosis can affect any large-to-medium-sized artery in the body and cause serious health problems.
In rare cases, the narrowing of carotid arteries can be caused by other conditions such as:
One type of intracranial vascular disease is moyamoya disease, the narrowing and ultimate closure of the internal carotid arteries, which has its own symptoms and recommended treatments.
At UPMC, extracranial and intracranial vascular disease may be treated medically or surgically, depending upon the severity of the disease.
To diagnose extracranial vascular disease, your doctor will:
Your doctor may request imaging tests to examine how blood flows through your arteries. These diagnostic tests include:
Symptoms vary depending on whether carotid or vertebral arteries are affected.
Carotid stenosis generally shows no symptoms until a complication occurs, such as a stroke or brain aneurysm occurs. However, some people experience warning symptoms of a stroke called a transient ischemic attack (TIA), which should be treated as a medical emergency, even if the symptoms go away.
TIAs are often warning signs of an imminent stroke.
Symptoms of a TIA include:
Symptoms of vertebral artery disease overlap with those of carotid artery disease and may include:
In cooperation with neurologists, cardiologists, and radiologists, UPMC’s neurovascular doctors take a multidisciplinary approach to recommend treatments that are least disruptive to a person's brain, critical nerves, and offer the ability to return to normal functioning.
Treatment for extracranial and intracranial vascular disease depends upon:
Extracranial and intracranial vascular disease can sometimes be prevented, though not reversed, by several lifestyle changes. To address atherosclerosis, people may be advised to:
This can help lower blood pressure and cholesterol, which in turn can slow the buildup of plaque in the arteries.
Along with lifestyle changes, medications are usually the most frequently recommended treatment. Common prescriptions include:
When stenosis severely restricts an artery, or a person has already suffered a stroke, an open surgical approach may be indicated.
A carotid endarterectomy consists of a small linear incision in the neck followed by dissection and localization of the carotid artery.
The artery is opened and all the “calcified fat” (atheroma) is removed from the artery to:
Brain waves are monitored during surgery to make sure the brain is receiving enough blood throughout the procedure.
Angioplasty involves inserting a thin tube called a catheter into an artery in the groin or leg and threading the catheter up to the affected artery
A small balloon at the end of the catheter is inflated at the blocked area, flattening the plaque buildup against the artery wall and widening the artery so blood flow is restored.
The procedure may be followed by stenting, which inserts a wire mesh tube called a stent into the artery to hold it open in the long term.
How can we help you?
Schedule anappointment >
Ask a question >
Request our expertopinion >
1-877-986-9862(within the U.S.)
Affiliated with the University of Pittsburgh Schools of the Health Sciences
Supplemental content provided by
A.D.A.M. Health Solutions. All rights reserved.
For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.
UPMC is an equal opportunity employer. UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, gender identity, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.
Medical information made available on UPMC.com is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, UPMC.com is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.
For UPMC Mercy Patients: As a Catholic hospital, UPMC Mercy abides by the Ethical and Religious Directives for Catholic Health Care Services, as determined by the United States Conference of Catholic Bishops. As such, UPMC Mercy neither endorses nor provides medical practices and/or procedures that contradict the moral teachings of the Roman Catholic Church.
Pittsburgh, PA, USA UPMC.com