Navigate Up

Changfeng Tai, PhD

Design and development of new neural prosthetic devices to restore urinary functions in neurological disorder conditions.

Special interests are focused on the control of both bladder and sphincter using electrical nerve stimulation. One of the goals for this research project is to restore the functions for urine storage and elimination after spinal cord injury.

Two urological problems need to be solved in people with spinal cord injury:

  1. How to inhibit the bladder over-activity during urine storage to prevent the frequent incontinence.
  2. How to inhibit the tonic contractions of urethral sphincter during voiding to completely eliminate urine.

Modeling analysis of electrical nerve stimulation.

This project is aimed at understanding the mechanisms and biophysics of nerve response to extra-cellular electrical stimulation. It is focused on how to design the stimulation electrodes and stimulation waveforms to either excite or block the nerves using electrical current. Modeling and computer simulations are extensively used in this project to elucidate the mechanisms underlying the axonal response to electrical stimulation. The results from this project could significantly improve the design of neural prosthetic devices to restore functions after neurological disorders.

Understanding the neurophysiology and neuropharmacology of the lower urinary tract.

This project is aimed at discovering new treatments.

Contact Information

Department of Urology
University of Pittsburgh
700 Kaufmann Building
3471 Fifth Ave.
Pittsburgh, PA 15213
Telephone: 412-692-4142
Fax: 412-692-4380

©  UPMC | Affiliated with the University of Pittsburgh Schools of the Health Sciences
Supplemental content provided by A.D.A.M. Health Solutions. All rights reserved.

For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.

UPMC is an equal opportunity employer. UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.

Medical information made available on UPMC.com is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, UPMC.com is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.

For UPMC Mercy Patients: As a Catholic hospital, UPMC Mercy abides by the Ethical and Religious Directives for Catholic Health Care Services, as determined by the United States Conference of Catholic Bishops. As such, UPMC Mercy neither endorses nor provides medical practices and/or procedures that contradict the moral teachings of the Roman Catholic Church.

© UPMC
Pittsburgh, PA, USA UPMC.com