Navigate Up

Cancer Center - A-Z Index

#
Q
Y

Print This Page

Hyperaldosteronism - primary and secondary

Hyperaldosteronism is a disorder in which the adrenal gland releases too much of the hormone aldosterone  into the blood.

Hyperaldosteronism can be primary or secondary.

Alternative Names

Conn syndrome; Mineralocorticoid excess

Causes

Primary hyperaldosteronism is due to a problem of the adrenal glands themselves, causing them to release too much aldosterone. In contrast, with secondary hyperaldosteronism, the adrenal glands release too much aldosterone as a result of a problem elsewhere in the body. These problems can be with genes, diet, or a medical disorder such as with the heart, liver, kidneys, or high blood pressure.

Most cases of primary hyperaldosteronism are caused by a noncancerous (benign) tumor of the adrenal gland. The condition is most common in people 30 to 50 years old.

Symptoms

Primary and secondary hyperaldosteronism have common symptoms, including:

Exams and Tests

Tests that may be ordered to diagnose hyperaldosteronism include:

A procedure to insert a catheter into the veins of the adrenal glands may need to be done. This helps check which of the two adrenal glands is making too much aldosterone.

This disease may also affect the results of the following tests:

Treatment

Primary hyperaldosteronism caused by an adrenal gland tumor is usually treated with surgery. It can sometimes be treated with medicines. Removing the adrenal tumor may control the symptoms. Even after surgery, some people still have high blood pressure and need to take medicine. But often, the number of medicines or doses can be lowered.

Limiting how much salt intake and taking medicine may control the symptoms without surgery. Medicines to treat hyperaldosteronism include:

  • Drugs that block the action of aldosterone
  • Diuretics (water pills), which help manage fluid buildup in the body

Secondary hyperaldosteronism is treated with medicines (as described above) and limiting salt intake. Surgery is not used.

Outlook (Prognosis)

The outlook for primary hyperaldosteronism is good with early diagnosis and treatment.

The outlook for secondary hyperaldosteronism depends on the cause of the condition.

Possible Complications

Impotence and gynecomastia (enlarged breasts in men) may occur with long-term use of medicines. But this is uncommon.

When to Contact a Medical Professional

Call for an appointment with your health care provider if you develop symptoms of hyperaldosteronism.

References

Ioachimescu AG, Hamrahian AH. Diseases of the adrenal gland. In: Cleveland Clinic: Current Clinical Medicine. 2nd ed. Elsevier Saunders; 2010:sec 4.

Nieman LK. Adrenal cortex. In: In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, Pa: Elsevier Saunders; 2011:chap 234.

Updated: 8/1/2013

Brent Wisse, MD, Associate Professor of Medicine, Division of Metabolism, Endocrinology & Nutrition, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.


©  UPMC | Affiliated with the University of Pittsburgh Schools of the Health Sciences
Supplemental content provided by A.D.A.M. Health Solutions. All rights reserved.

For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.

UPMC is an equal opportunity employer. UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.

Medical information made available on UPMC.com is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, UPMC.com is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.

For UPMC Mercy Patients: As a Catholic hospital, UPMC Mercy abides by the Ethical and Religious Directives for Catholic Health Care Services, as determined by the United States Conference of Catholic Bishops. As such, UPMC Mercy neither endorses nor provides medical practices and/or procedures that contradict the moral teachings of the Roman Catholic Church.

© UPMC
Pittsburgh, PA, USA UPMC.com