Paget’s disease of the bone
Paget's disease is a disorder that involves abnormal bone destruction and regrowth. This results in deformity of the affected bones.
The cause of Paget's disease is unknown. It may be due to genetic factors or a viral infection early in life.
The disease occurs worldwide, but is more common in Europe, Australia, and New Zealand.
In people with Paget's disease, there is an abnormal breakdown of bone tissue in specific areas. This is, followed by abnormal bone formation. The new area of bone is larger, but weaker. The new bone is also filled with new blood vessels.
The affected bone may only be in one or two areas of the skeleton, or throughout the body. It more often involves bones of the arms, collarbones, leg, pelvis, spine, and skull.
Most people with the condition have no symptoms. Paget's disease is often diagnosed when an x-ray is done for another reason. It may also be discovered when trying to find the cause of high blood calcium levels.
If they do occur, symptoms may include:
- Bone pain
, joint pain or stiffness, and neck pain (the pain may be severe and present most of the time)
- Bowing of the legs and other visible deformities
- Enlarged head and skull deformities
- Hearing loss
- Reduced height
- Warm skin over the affected bone
Exams and Tests
Tests that may indicate Paget's disease include:
This disease may also affect the results of the following tests:
Not all people with Paget’s disease need to be treated. Patients who may not need treatment include those who:
- Only have abnormal blood tests
- Have no symptoms and no evidence of active disease
Paget's disease is commonly treated when:
- Certain bones, such as weight-bearing bones, are involved.
- Bony changes are getting worse quickly (treatment can reduce the risk of fractures).
- Bony deformities are present.
- A person has pain or other symptoms.
- The skull is affected. (This is to prevent hearing loss.)
Drug therapy helps prevent further bone breakdown and formation. Currently, there are several classes of drugs used to treat Paget's disease. These include:
- Bisphosphonates. These drugs are the first treatment, and they help decrease bone remodeling. Medicines are commonly taken by mouth, but can also begiven through a vein (intravenously).
- Calcitonin. This hormone is involved in bone metabolism. It may be given as a nasal spray (Miacalcin), or as an injection under the skin (Calcimar or Mithracin)
Acetaminophen (Tylenol) or non-steroidal anti-inflammatory medications (NSAIDs) may also be given for pain. In severe cases, orthopedic surgery may be needed to correct a deformity.
Most of the time, the condition can be controlled with medicines. A small number of people may develop a cancer of the bone called osteosarcoma. Some patients will need joint replacement surgery.
When to Contact a Medical Professional
Call your health care provider if you develop symptoms of Paget's disease.
Lorenzo JA, Canalis E, Raisz LG. Metabolic bone disease. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 29.
Brent Wisse, MD, Associate Professor of Medicine, Division of Metabolism, Endocrinology & Nutrition, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.