Shiga-like toxin producing E. coli hemolytic-uremic syndrome (STEC-HUS) is a disorder that usually occurs when an infection in the digestive system produces toxic substances that destroy red blood cells, causing kidney injury.
Hemolytic-uremic syndrome (HUS) often occurs after a gastrointestinal infection with E. coli bacteria (Escherichia coli O157:H7). However, the condition has also been linked to other gastrointestinal infections, including shigella
, as well as nongastrointestinal infections.
HUS is most common in children. It is the most common cause of acute kidney failure in children. Several large outbreaks in 1992 and 1993 were linked to undercooked hamburger meat contaminated with E. coli.
STEC-HUS is not to be confused with atypical HUS (aHUS) which is not infection-related and is similar to another disease called thrombotic thrombocytopenic purpura
STEC-HUS often begins with vomiting and diarrhea, which may be bloody. Within a week, the person may become weak and irritable. Persons with this condition may urinate less than normal. Urine output may almost stop.
Red blood cell destruction leads to symptoms of anemia
Exams and Tests
The health care provider will perform a physical exam. This may show:
Liver or spleen swelling
Nervous system changes
Laboratory tests will show signs of hemolytic anemia
and acute renal failure
. Tests may include:
Treatment may involve:
This is a serious illness in both children and adults, and it can cause death. With proper treatment, more than half of patients will recover. The outcome is better in children than adults.
When to Contact a Medical Professional
Call your health care provider if you develop symptoms of HUS. Emergency symptoms include:
Call your health care provider if you have had an episode of HUS and your urine output decreases, or you develop other new symptoms.
You can prevent the known cause, E. coli, by cooking hamburger and other meats well and by avoiding contact with unclean water.
Abrams CS. Thrombocytopenia. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 175.
Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.