Alström syndrome is a very rare disease passed down through families (inherited) that can lead to blindness
, and obesity
Alström syndrome is inherited in an autosomal recessive
manner. This means both your parents must pass on a copy of the defective gene (ALMSI) in order for you to have this disease.
It is unknown how the defective gene causes the disorder.
The condition is extremely rare. It is more common in Holland and Sweden than in the United States.
- Blindness or severe vision impairment
- Dark patches of skin (acanthosis nigricans)
- Impaired heart function (cardiomyopathy
), which may lead to heart failure
- Progressive kidney failure
- Slowed growth
- Symptoms of childhood-onset or type 2 diabetes
Occasionally, the following can also occur:
Exams and Tests
An eye doctor (ophthalmologist) will examine the eyes. The patient may have reduced vision.
Tests may be done to check:
There is no specific treatment for this syndrome. Treatment for symptoms may include:
The following are likely to develop:
Type 2 diabetes
Kidney and liver failure may get worse.
When to Contact a Medical Professional
Call your health care provider if you or your child has symptoms of diabetes, such as increased thirst and urination. Seek medical attention right away if you think that your child cannot see or hear normally.
Torres VE, Grantham JJ. Cystic diseases of the kidney. In: Taal MW, Chertow GM, Marsden PA, et al, eds. Brenner and Rector's The Kidney. 9th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 45.
Neil K. Kaneshiro, MD, MHA, Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.