​CAPABLE Clinical Trials

Are you one of the many American women that struggles with fecal incontinence?

Fecal incontinence is also called accidental bowel leakage. Many women experience this very embarrassing problem which can be difficult to manage.

Doctors recommend a number of non-surgical treatments for fecal incontinence. They include:

  • Changes in diet and behaviors
  • Medications: Often a large number of women with fecal incontinence will complain of leaking only with loose or watery stools. Anti-diarrhea medications such as loperamide (Imodium) are at times prescribed to help create more formed stools and decrease urgent feelings of needing to go to the bathroom. Currently this medication is not prescribed routinely for women who have only fecal incontinence although it is frequently prescribed for women who complain of fecal incontinence and loose or watery stools.
  • Pelvic muscle training exercises: Working with a physical therapist or specialist in pelvic floor muscle and behavioral therapy has been shown to be helpful for all types of incontinence. It includes pelvic floor muscle therapy, designed to strengthen and improve coordination of the pelvic floor muscles to control leakage.

What is the CAPABLE study?

The goal of the CAPABLE study is to learn more about the last two treatments: medications and pelvic muscle training. Specifically, this study will compare the following treatments for fecal incontinence to see if one treatment or both together are better than usual care at improving fecal incontinence:

  • Loperamide only
  • Pelvic muscle training only
  • Loperamide and pelvic muscle training together
  • Usual care / placebo pill

Women will be randomly assigned to one of the four groups above. Treatment will continue for 6 months. Women will report their symptoms throughout the study by answering questionnaires and completing a bowel diary.

Recruitment began in March of 2014. The results are expected to be available in the spring of 2017.

For more information about this study please contact Karen Mislanovich RN, the study coordinator, at 412-641-6679 or


Contact Us

Women's Center for Bladder and Pelvic Health
Magee-Womens Hospital of UPMC
300 Halket Street
Pittsburgh, PA 15213


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