Research Study Available for Older Adults Living with Low Back Pain and Depression
Both low back pain and clinical depression are common in seniors, and up to 25 percent of older adults suffer from both conditions at the same time, said principal investigator Jordan F. Karp, M.D
., associate professor of psychiatry, University of Pittsburgh School of Medicine.
“Chronic low back pain and depression make each other worse, have similar risk factors, and increase the likelihood of each other’s recurrence,” he said. “Both can cause poor sleep and subsequent daytime drowsiness, keep people from participating or enjoying their usual activities, and isolate them at home. When they are both present, patients can enter a vicious cycle of the blues, pain, physical deconditioning, and feeling hopeless.”
For the ADAPT study, adults 60 or older who have depression symptoms and low back pain on most days for at least three months will participate in the first stage during which everyone takes the anti-depressant drug venlafaxine, also known as Effexor. Participants who have not improved after the first six weeks then have the opportunity to continue in the study for an additional 14 weeks, and be randomly assigned to receive a higher dose of venlafaxine alone or in combination with a counseling program that teaches problem-solving skills specific for managing pain, mood, sleep, and other difficulties commonly experienced by seniors living with these linked conditions.
At low doses, venlafaxine increases the levels of the neurotransmitter serotonin, which regulates mood. At higher doses, the drug also increases levels of the neurotransmitter norepinephrine, which regulates both mood and pain, Dr. Karp said.
“Venlafaxine has been approved for the treatment of anxiety and depression, and it is a widely used, well-tolerated drug,” he said. “Getting people moving and in better control of their pain through healthy behavior changes also may help their mood and improve quality of life.”
According to Dr. Karp, the goal of the study is to learn whether people who do not improve with low-dose venlafaxine alone need the addition of the problem-solving therapy to get them feeling better.