Topotecan Hydrochloride (Generic Name)
Other Names: Hycamtin™
About This Drug
Topotecan hydrochloride is used to treat cancer. This drug is given intravenously (IV).
Possible Side Effects
- Bone marrow depression. This is a decrease in the number of white blood cells, red blood cells, and platelets. Bone marrow depression usually occurs seven to 14 days after this drug is given and may increase your risk of infection, fatigue, and bleeding.
- Nausea and vomiting
- Hair loss. Most patients experience scalp and body hair loss. You may notice hair thinning several days after receiving this drug. Usually hair loss is temporary; your hair should grow back when treatment is complete.
- Skin and tissue irritation. You may have redness, pain, warmth, or swelling at the IV site. This irritation occurs if the drug leaks out of the vein and into surrounding tissue.
- Diarrhea that lasts for several days
- Trouble breathing
- Raised, red rash on your arms, legs, back, or chest
- Soreness of the mouth and throat. You may have red areas, white patches, or sores that are painful.
- Decreased appetite
- Sexual problems and reproduction concerns may occur. In men and women both, this drug may temporarily or permanently affect your ability to have children. This cannot be determined before your therapy. In men, this drug may interfere with your ability to make sperm, but it should not change your ability to have sexual relations. In women, menstrual bleeding may become irregular or stop while you are receiving this drug. Do not assume that you cannot become pregnant if you do not have a menstrual period. Women may have signs of menopause like vaginal dryness or itching.
- This drug may have harmful effects on the unborn child, so effective methods of birth control should be used during your cancer treatment.
- Genetic counseling is available to you to discuss the effect of this drug therapy on future pregnancies. In addition, a genetic counselor can review the potential risks of problems in the fetus due to this medication if an exposure during pregnancy has occurred.
Treating Side Effects
- Mouth care is very important. Your mouth care should consist of gently brushing with a very soft tooth brush and rinsing your mouth with a mixture of 1/2 teaspoon of salt in 8 ounces of water or 1/2 teaspoon of sodium bicarbonate (baking soda) in 8 ounces of water. Do this at least after every meal and at bedtime.
- Avoid mouthwash that contains alcohol. Avoid alcohol and smoking because they can irritate your mouth and throat.
- Ask your doctor or nurse about medication that is available to help prevent or lessen nausea and vomiting.
- Talk to your doctor or nurse about obtaining a wig before you have a lot of hair loss.
- Do not put anything on your rash unless your doctor or nurse says you may. Keep the area around the rash clean and dry.
- Use effective methods of birth control during your cancer treatment.
- Vaginal lubricants can be used to lessen vaginal dryness, itching, and pain during sexual relations.
- Speak with your doctor or nurse if you plan to have children. Ask for information on sperm or egg banking.
- Talk with your doctor or nurse if you feel you need help with your mood.
Food and Drug Interactions
There are no known interactions of topotecan hydrochloride and any food. This drug may interact with other medications. Tell your doctor and pharmacist all the medications that you are currently taking.
When to Call the Doctor
Call your doctor or nurse immediately if you have any of the following symptoms:
- Temperature of 100.5 F (38 C) or above
- Shortness of breath
- Unusual bleeding or bruising
- Uncontrolled nausea that prevents you from eating or drinking
- Vomiting more than three times in one day
- Redness, pain, warmth, or swelling at the IV site
Notify your doctor or nurse as soon as possible if you have any of the following symptoms:
- Painful mouth or throat that makes it difficult to eat or drink
- Diarrhea of five or six stools in one day
- Diarrhea with weakness or lightheadedness
- Nausea unrelieved by prescribed medication
- Headache unrelieved by prescribed medication
- No bowel movement for three days or if you become uncomfortable
- Abdominal pain
- Persistent loss of appetite or loss of five pounds or more in one week
- Extreme tiredness that interferes with normal activities
- Rash that is bothersome