​​Atezolizumab (Generic Name)

Other Names: Tecentriq ®

About this Drug:

(Atezolizumab) is used to treat cancer. It is given intravenously (IV).

Possible Side Effects (More Common)

  • Feeling tired
  • Constipation (not able to move bowels)
  • Decreased appetite (decreased hunger)
  • Nausea and throwing up (vomiting). These symptoms may happen within a few hours after your treatment and may last up to 24 hours. Medicines are available to stop or lessen these side effects.
  • Urinary tract infection. Symptoms may include:
    • Pain or burning when you pass urine.
    • Feeling like you have to pass urine often, but not much comes out when you do.
    • Tender or heavy feeling in your lower abdomen.
    • Cloudy urine and/or urine that smells bad.
    • Pain on one side of your back under your ribs. This is where your kidneys are.
    • Fever, chills, nausea and/or throwing up.
  • Flu-like symptoms: fever, headache, muscle and joint aches, and fatigue (low energy, feeling weak)

Possible Side Effects (Less Common)

  • Rash
  • Changes in your liver function. Your doctor will check your liver function as needed
  • Colitis which is swelling in the colon. The symptoms are loose bowel movements (diarrhea), stomach cramping, and sometimes blood in the bowel movements.
  • Loose bowel movements (diarrhea) that may last for a few days
  • Changes in the lung tissue may happen. These changes may not last forever, and your lung tissue may go back to normal. Sometimes these changes may not be seen for many years. You may get a cough or have trouble catching your breath.

Treating Side Effects

  • If you get a rash do not put anything on it unless your doctor or nurse says you may. Keep the area around the rash clean and dry. Ask your doctor for medicine if your rash bothers you.
  • Drink 6-8 cups of fluids each day unless your doctor has told you to limit your fluid intake due to some other health problem. A cup is 8 ounces of fluid. If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack of water in the body from losing too much fluid).
  • Ask your doctor or nurse about medicine that is available to help stop or lessen the loose bowel movements.
  • If you are not able to move your bowels, check with your doctor or nurse before you use enemas, laxatives, or suppositories.
  • If you get symptoms of a bladder infection, please call your doctor or nurse right away. You may be given antibiotics to treat the infection and/or medicines to help the symptoms.
  • Ask your doctor or nurse about medicine that is available to help stop or lessen fever, headache, muscle and joint aches.

Food and Drug Interactions

There are no known interactions of atezolizumab with food. This drug may interact with other medications. Tell your doctor and pharmacist about all the medication and dietary supplements (vitamins, minerals, herbs, and others) that you are currently taking. The safety and effectiveness of dietary supplements and alternative diets are often unknown. Using these might unexpectedly affect your cancer or interfere with your treatment. Until more is known, you should not use dietary supplements or alternative diets without your cancer doctor's advice.

When to Call the Doctor

Call your doctor or nurse immediately if you have any of the following symptoms:

  • Loose bowel movements (diarrhea) 4 times or loose bowel movements with lack of strength or a feeling of being dizzy
  • Fever of 100.5 F (38 C) or higher
  • Chills
  • Easy bleeding or bruising
  • Wheezing or trouble breathing
  • Rash or itching
  • Pain when passing urine
  • Feeling dizzy or lightheaded
  • Nausea that stops you from eating or drinking
  • Signs of liver problems: dark urine, pale bowel movements, bad stomach pain, feeling very tired and weak, unusual itching, or yellowing of the eyes or skin

Call your doctor or nurse as soon as possible if any of the following symptoms occur:

  • Decreased urine
  • Blurred vision or other changes in eyesight
  • Rash that is not relieved by prescribed medicines
  • Swelling of legs, ankles, or feet
  • Weight gain of 5 pounds in one week (fluid retention)
  • Fatigue that interferes with your daily activities
  • Headache that does not go away
  • Extreme weakness that interferes with normal activities

Reproduction Concerns

  • Pregnancy warning: this drug may have harmful effects on the unborn child, so effective methods of birth control should be used during your cancer treatment and for at least 5 months after treatment has been stopped.
  • Breast feeding warning: Women should not breast feed during treatment and for at least 5 months after treatment has been stopped because this drug could enter the breast milk and badly harm a breast feeding baby.

UPMC | Affiliated with the University of Pittsburgh Schools of the Health Sciences | Supplemental content provided by Healthwise, Incorporated. To learn more, visit www.healthwise.org

For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.

UPMC is an equal opportunity employer. UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, gender identity, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.

Medical information made available on UPMC.com is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, UPMC.com is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.

Pittsburgh, PA, USA | UPMC.com