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Telotristat Ethyl (Xermelo®)

About This Drug

Telotristat ethyl is used to treat diarrhea in patients with carcinoid syndrome. It is given orally (by mouth).

Possible Side Effects

  • Nausea
  • Decreased appetite (decreased hunger)
  • Excess gas
  • Changes in your liver function. Your doctor will check your liver function as needed
  • Headache
  • Depression
  • Fever
  • Swelling of your legs, ankles and/or feet

Note: Each of the side effects above was reported in 5% or greater of patients treated with telotristat ethyl. Not all possible side effects are included above.

Warnings and Precautions

  • Constipation (not able to move bowels)

How to Take Your Medication

  • Take your medicine with food.
  • Missed doses: If you vomit or miss a dose, take your next dose at the regular time. Do not take 2 doses at the same time.
  • Handling: Wash your hands after handling your medicine, your caretakers should not handle your medicine with bare hands and should wear latex gloves.
  • Storing: Store this medicine in the original container at room temperature. Discuss with your nurse or your doctor how to dispose of unused medicine.

Treating Side Effects

  • Drink plenty of fluids (a minimum of eight glasses per day is recommended).
  • If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack water in the body from losing too much fluid).
  • To help with nausea and vomiting, eat small, frequent meals instead of three large meals a day. Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help or stop lessen these symptoms.
  • To help with decreased appetite, eat small, frequent meals.
  • Eat high caloric food such as pudding, ice cream, yogurt and milkshakes.
  • To help with excess gas, avoid gas-producing foods.
  • If you are not able to move your bowels, check with your doctor or nurse before you use enemas, laxatives, or suppositories.
  • Keeping your pain under control is important to your well-being. Please tell your doctor or nurse if you are experiencing pain.
  • If you are feeling depressed, talk to your nurse or doctor about it.

Food and Drug Interactions

  • There are no known interactions of telotristat ethyl with food.
  • Check with your doctor or pharmacist about all other prescription medicines and dietary supplements you are taking before starting this medicine as there are known drug interactions with telotristat ethyl. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplement to make sure that there are no interactions.

When to Call the Doctor

Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:

  • Fever of 100.5 F (38 C) or higher
  • Chills
  • Severe abdominal pain/cramping
  • Nausea that stops you from eating and drinking and/or that is not relieved by prescribed medicine
  • Lasting loss of appetite or rapid weight loss of five pounds in a week
  • No bowel movement in 3 days or when you feel uncomfortable
  • Swelling of your legs, ankles and/or feet
  • Headache that does not go away
  • If you think you are pregnant

Reproduction Warnings

  • Pregnancy warning: It is not known if this drug may harm an unborn child. For this reason, be sure to talk with your doctor if you are pregnant or planning to become pregnant while getting this drug. Let your doctor know right away if you think you may be pregnant.
  • Breast feeding warning: It is not known if this drug passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breast feeding during treatment with this drug because this drug may enter the breast milk and cause harm to a breast feeding baby. If you are breastfeeding, monitor your baby for signs of constipation.

New June 2017

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