Trifluridine-Tipiracil
Other Names: Lonsurf®

About This Drug

This drug is used to treat cancer. It is given my by mouth (orally).

Possible Side Effects (More Common)

  • Bone marrow depression. This is a decrease in the number of white blood cells, red blood cells, and platelets. This may raise your risk of infection, make you tired and weak (fatigue), and raise your risk of bleeding.
  • Nausea and throwing up (vomiting). Medicines are available to stop or lessen these side effects
  • Tiredness
  • Decreased appetite (decreased hunger)
  • Loose bowel movements (diarrhea) that may last for a few days

Possible Side Effects (Less Common)

  • Soreness of the mouth and throat. You may have red areas, white patches, or sores that hurt.
  • Changes in the way food and drinks taste

Treating Side Effects

  • Drink 6-8 cups of fluids each day unless your doctor has told you to limit your fluid intake due to some other health problem. A cup is 8 ounces of fluid. If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack water in the body from losing too much fluid).
  • Ask your doctor or nurse about medicine that is available to help stop or lessen the loose bowel movements.
  • Mouth care is very important. Your mouth care should consist of routine, gentle cleaning of your teeth or dentures and rinsing your mouth with a mixture of ½ teaspoon of salt in 8 ounces of water or ½ teaspoon of baking soda in 8 ounces of water. This should be done at least after each meal and at bedtime.
  • If you have mouth sores, avoid mouthwash that has alcohol. Also avoid alcohol and smoking because they can bother your mouth and throat.

Important Information

  • Take this drug by mouth within 1 hour after eating.
  • Swallow the medicine whole. Do not chew, break or crush it.
  • Take this medicine at the same time each day
  • Store this medicine in the original container at room temperature
  • If you miss a dose of trifluridine and tipiracil do not take the missed dose at all and do not double up on the next dose. Instead, continue with your regular dosing schedule and contact your physician.

Food and Drug Interactions

  • There are no known interactions of trifluridine and tipiracil with food. This drug may interact with other medications. Tell your doctor and pharmacist about all the medication and dietary supplements (vitamins, minerals, herbs, and others) that you are currently taking. The safety and effectiveness of dietary supplements and alternative diets are often unknown. Using these might unexpectedly affect your cancer or interfere with your treatment. Until more is known, you should not use dietary supplements or alternative diets without your cancer doctor's advice.

When to Call the Doctor

Call your doctor or nurse immediately if you have any of the following symptoms:

  • Fever of 100.5 F (38 C) or higher
  • Chills
  • Easy bleeding or bruising
  • Feeling dizzy or lightheaded
  • Loose bowel movements (diarrhea) more than 4 times a day or diarrhea with weakness or lightheadedness
  • Pain when passing urine; blood in urine
  • Pain in your lower back or side
  • Nausea that stops you from eating or drinking
  • Throwing up more than 3 times a day

Call your doctor or nurse as soon as possible if any of the following symptoms occur:

  • Pain in your mouth or throat that makes it hard to eat or drink
  • Nausea that is not relieved by prescribed medicines
  • Heavy menstrual period that lasts longer than normal
  • Lasting loss of appetite or rapid weight loss of five pounds in a week
  • Extreme weakness that interferes with normal activities

Reproduction Concerns

  • Pregnancy warning: This drug may have harmful effects on the unborn child, women should use effective methods of birth control during cancer treatment. Men should use condoms during treatment and for at least 3 months following final dose. Genetic counseling is available for you to talk about the effects of this drug therapy on future pregnancies. Also, a genetic counselor can look at the possible risk of problems in the unborn baby due to this medicine if an exposure happens during pregnancy.
  • Breast feeding warning: It is not known if this drug passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breast feeding during treatment with this drug because this drug may enter the breast milk and badly harm a breast feeding baby.

Updated January 2017

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