Navigate Up
Show the Banner?

Soft Tissue Sarcoma

What Is Soft Tissue Sarcoma?

Soft tissue sarcomas are cancerous tumors that come from the connective tissues (muscle, fat, tendon, nerve).

Soft tissue sarcoma often appears in the following locations:

  • Thigh
  • Buttocks
  • Calf
  • Arm
  • Abdomen

Soft tissue sarcoma causes and risk factors

Soft tissue sarcomas can occur at any age, but are most common in older adults.

Soft tissue sarcoma types

Two subtypes of soft tissue sarcoma are:

  • Rhabdomyosarcoma, which occurs in children.
  • Synovial sarcoma, which occurs in teenagers and young adults.

Soft Tissue Sarcoma Symptoms

Symptoms of soft tissue sarcoma include a growing, painless mass.

Most soft tissue sarcomas do not hurt.

Soft Tissue Sarcoma Treatment

Soft tissue sarcoma is serious, but both curable and treatable.

Soft tissue sarcoma surgery

Soft tissue sarcoma treatment nearly always involves surgery, often with radiation. Doctors may prescribe chemotherapy in certain situations, depending on patient and disease factors.

Make an Appointment for Soft Tissue Sarcoma Care

Request an appointment with a UPMC orthopaedic surgeon:

Show the Feature Bar?

UPMC | Affiliated with the University of Pittsburgh Schools of the Health Sciences | Supplemental content provided by Healthwise, Incorporated. To learn more, visit

For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.

UPMC is an equal opportunity employer. UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.

Medical information made available on is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.

For UPMC Mercy Patients: As a Catholic hospital, UPMC Mercy abides by the Ethical and Religious Directives for Catholic Health Care Services, as determined by the United States Conference of Catholic Bishops. As such, UPMC Mercy neither endorses nor provides medical practices and/or procedures that contradict the moral teachings of the Roman Catholic Church.

Pittsburgh, PA, USA |