About this Drug:
Daratumumab is a medication used to treat a type of cancer called multiple myeloma. It is given intravenously (IV).
Possible Side Effects (More Common)
- Flu-like symptoms: fever, headache, muscle and joint aches, and fatigue (low energy, feeling weak).
- Cold-like symptoms: coughing, nasal congestion, and sore throat.
- While you are getting this drug in your vein (IV), you may have a reaction to the drug. Your nurse will check you closely for these signs: fever or shaking chills, flushing, facial swelling, feeling dizzy, headache, trouble breathing, rash, itching, chest tightness, or chest pain. You will be given medicines to help stop or lessen these symptoms. These reactions may happen for 48 hours after your infusion. If this happens, call 911 for emergency care.
- Nausea and throwing up (vomiting). Medicines are available to stop or lessen these side effects.
- Bone marrow depression. This is a decrease in the number of white blood cells, red blood cells and platelets. This may raise your risk of infection, may make you tired and weak (fatigue), and raise your risk of bleeding.
Possible Side Effects (Less Common)
- Shingles reactivation. If you have had shingles (herpes zoster infection) before, it may come back. Symptoms of shingles are burning or shooting pain and tingling or itching, often on one side of the body or face. The pain can be mild to very bad. You will be given a medicine to help lessen this from happening.
- High blood pressure. Your doctor will check your blood pressure as needed.
- Decreased appetite (decreased hunger)
- This medication can affect the results of blood tests that match your blood type. Your blood type will be tested before treatment. Be sure to tell all healthcare providers you are taking this medicine before receiving blood transfusions, even for 6 months after your last dose.
Treating Side Effects
- Drink 6-8 cups of fluids each day unless your doctor has told you to limit your fluid intake due to some other health problem. A cup is 8 ounces of fluid. If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack of water in the body from losing too much fluid).
- Ask your doctor or nurse about medicine that is available to help stop or lessen fever, headache, muscle and joint aches.
Food and Drug Interactions
- There are no known interactions of daratumumab with food. This drug may interact with other medications. Tell your doctor and pharmacist about all the medication and dietary supplements (vitamins, minerals, herbs, and others) that you are currently taking. The safety and effectiveness of dietary supplements and alternative diets are often unknown. Using these might unexpectedly affect your cancer or interfere with your treatment. Until more is known, you should not use dietary supplements or alternative diets without your cancer doctor's advice.
When to Call the Doctor
Call your doctor or nurse immediately if you have any of the following symptoms:
- Loose bowel movements (diarrhea) 4 times or loose bowel movements with lack of strength or a feeling of being dizzy
- Fever of 100.5 F (38 C) or higher
- Easy bleeding or bruising
- Wheezing or trouble breathing
- Rash or itching
- Feeling dizzy or lightheaded
- Nausea that stops you from eating or drinking
- Signs of liver problems: dark urine, pale bowel movements, bad stomach pain, feeling very tired and weak, unusual itching, or yellowing of the eyes or skin
Call your doctor or nurse as soon as possible if any of the following symptoms occur:
- Decreased urine
- Blurred vision or other changes in eyesight
- Rash that is not relieved by prescribed medicines
- Swelling of legs, ankles, or feet
- Weight gain of 5 pounds in one week (fluid retention)
- Fatigue that interferes with your daily activities
- Headache that does not go away
- Extreme weakness that interferes with normal activities
- Pregnancy warning: this drug may have harmful effects on the unborn child, so effective methods of birth control should be used during your cancer treatment and for at least 3 months after treatment has been stopped.
- Breast feeding warning: It is not known if this drug passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breast feeding during treatment with this drug because this drug may enter the breast milk and badly harm a breast feeding baby.