Aprepitant or fosaprepitant is a medication used before chemotherapy to prevent you from becoming nauseous or throwing up (vomiting) during chemotherapy. It is given by an intravenous (IV) infusion or as an oral tablet by mouth.
Tell your doctor or nurse if you have burning, pain, itching, or a bump under your skin where the needle is placed.
Serious allergic reactions including anaphylaxis are rare. While you are getting this drug in your vein (IV), tell your nurse right away if you have any of these symptoms of an allergic reaction:
Tell your doctor if you are pregnant or breastfeeding. Birth control pills may not work as well while you are taking this medication, so use another form of birth control (such as a condom) during treatment and for 1 month after treatment. If you are taking a blood thinner such as warfarin, your doctor may need to check your blood after you receive this medication.
There are no known interactions of aprepitant or fosaprepitant with food. This drug may interact with cisapride and pimozide, so you should not receive this medication together with them. Tell your doctor or pharmacist if you are using diltiazem, rifampin, tolbutamide, a blood thinner (warfarin), a steroid (such as dexamethasone), medicine for seizures (phenytoin or carbamazepine), a sedative (such as alprazolam, midazolam, triazolam), medicine for depression (such as paroxetine), medicine for an infection (such as clarithromycin or itraconazole) or medicine for HIV/AIDS (such as ritonavir). Tell your doctor and pharmacist about all the medication and dietary supplements (vitamins, minerals, herbs, and others) that you are currently taking. The safety and effectiveness of dietary supplements and alternative diets are often unknown. Using these might unexpectedly affect your cancer or interfere with your treatment. Until more is known, you should not use dietary supplements or alternative diets without your cancer doctor's help.
Call your doctor or nurse immediately if you have any of the following symptoms:
Call your doctor or nurse as soon as possible if any of the following symptoms occur: