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Lenvatinib (Generic Name) Other Names: Lenvima®

UPMC Content 2

About This Drug:

Lenvatinib is used to treat cancer. It is given by mouth.

Possible Side Effects (More Common)

  • High Blood Pressure. Your doctor will check your blood pressure as needed.
  • Tiredness
  • Hand-and-foot syndrome. The palms of your hands or soles of your feet may tingle, become numb, painful, swollen, or red
  • Rash
  • Loose bowel movements (diarrhea) that may last for a few days
  • Generalized weakness and discomfort (aches or pains
  • Nausea and throwing up (vomiting). Medicines are available to stop or lessen these side effects.

Possible Side Effects (Less Common)

  • This drug may affect how your kidneys work. Your kidney function will be checked as needed.
  • Slow wound healing
  • Electrolyte changes. Your blood will be checked for electrolyte changes as needed.
  • Protein in urine. Your doctor will check your urine as needed.
  • Changes in your liver function. Your doctor will check your liver function as needed.

Allergic Reactions

Allergic reactions to this drug are rare, but may happen in some patients. Signs of allergic reactions to this drug may be a rash, fever, chills, feeling dizzy, trouble breathing, and/or feeling that your heart is beating in a fast or not normal way. If you get any of these symptoms do not take another dose of this drug. You should get urgent medical treatment.

Treating Side Effects

  • Drink 6-8 cups of fluids each day unless your doctor has told you to limit your fluid intake due to some other health problem. A cup is 8 ounces of fluid. If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack water in the body from losing too much fluid).
  • Ask your doctor or nurse about medicine that is available to help stop or lessen nausea, throwing up (vomiting, or loose bowel movements.
  • If you get a rash do not put anything on it unless your doctor or nurse days you may. Keep the area around the rash clean and dry. Ask your doctor for medicine if your rash bothers you.

Important Information

  • You can take this medicine with or without food. If you have nausea, take it with food.
  • Swallow the medicine whole. Do not chew, break or crush it
  • Take this medicine at the same time each day
  • Store lenvatinib at room temperature, between 68°F to 77°F (20°C to 25°C)
  • Missed dose: If you miss a dose take it as soon as you remember. If it is within 12 hours of your next dose just take your next dose at your normal time.
  • Disposal of Oral Chemotherapy Drugs
    • There may be a time when you have extra chemotherapy pills that you do not need. It is important to get rid of them in a safe way.
    • Call your pharmacy that filled the prescription and ask if they can take the extra pills back. Some pharmacies may do this, but the law does not tell them they have to.
    • Keep your pills in a safe place (away from children and pets) and take them back to a pharmacy that has a “National Prescription Drug Take-Back Day”. This is often done in September or October. For more information, go to
    • If you get rid of extra pills in an unsafe way it can harm other people, animals, and the environment.
      • Flush them down the toilet
      • Wash them down the sink
      • Put them in the trash

Food and Drug Interactions

There are no known interactions of lenvatinib with food. This drug may interact with other medicines. Tell your doctor and pharmacist about all the medicines and dietary supplements (vitamins, minerals, herbs and others) that you are taking at this time. The safety and use of dietary supplements and alternative diets are often not known. Using these might affect your cancer or interfere with your treatment. Until more is known, you should not use dietary supplements or alternative diets without your cancer doctor's help.

When to Call the Doctor

Call your doctor or nurse right away if you have any of these symptoms:

  • Chest pain or symptoms of heart attack. Most heart attacks involve pain in the center of the chest that lasts more than a few minutes. The pain may go away and come back or it can constant. It can feel like pressure, squeezing, fullness, or pain. Sometimes pain is felt in one or both arms, the back, neck, jaw, or stomach. If any of these symptoms last 2 minutes, call 911.
  • Loose bowel movements (diarrhea) 4 times in one day, or loose bowel movements with lack of strength or a feeling of being dizzy
  • Fever of 100.4 F (38 C) or higher
  • Chills
  • Easy bleeding or bruising
  • Feeling dizzy or lightheaded
  • Feeling that your heart is beating in a fast or not normal way (palpitations)
  • Feeling confused or agitated
  • Nausea that stops you from eating or drinking
  • Throwing up more than 3 times a day
  • Signs of liver problems: dark urine, pale bowel movements, bad stomach pain, feeling very tired and weak, unusual itching, or yellowing of the eyes or skin

Call your doctor or nurse as soon as possible if any of these symptoms happen:

  • Nausea that is not relieved by prescribed medicines
  • Fatigue that interferes with your daily activities

Reproduction and Sexual Concerns

  • Prgnancy warning: This drug may have harmful effects on the unborn baby, so effective methods of birth control should be used by both men and women during your cancer treatment and for at least 2 weeks after treatment has stopped.
  • Breast feeding warning: It is not known if this drug passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breast feeding during treatment with this drug because this drug may enter the breast milk and badly harm a breast feeding baby.
  • Infertility: Sexual problems and reproduction concerns may happen. In both men and women, this drug may affect your ability to have children. This cannot be determined before your therapy. Talk with your doctor or nurse if you plan to have children. Ask for information on sperm or egg banking.
  • Genetic counseling is available for you to talk about the effects of this drug therapy on future pregnancies. Also, a genetic counselor can look at the possible risk of problems in the unborn baby due to this medicine if an exposure happens during pregnancy.

New education sheet: June 2015