Percutaneous Hepatic Perfusion Treatment

Percutaneous hepatic perfusion (PHP) is similar to isolated hepatic perfusion (IHP), but is considered a minimally invasive procedure because we only need to make small needle punctures in the skin to access your liver, rather than a large incision. PHP does not open the body to expose any organs or tissues.

What Can I Expect During Percutaneous Hepatic Perfusion?

During PHP, our surgeons insert a special catheter, with a balloon on either end, through several needle punctures in the skin.

  • Once the catheters are in place, the balloons are inflated to seal off the vein above and below the liver to isolate it.
  • The blood inside the liver is removed and high-dose, heated chemotherapy is infused throughout the liver on a circuit using charcoal filters to remove chemotherapy from the blood as it is returned to the body.

People with liver-only disease respond well to the treatment.

Cancer Types Treated With Percutaneous Hepatic Perfusion:

UPMC | Affiliated with the University of Pittsburgh Schools of the Health Sciences | Supplemental content provided by Healthwise, Incorporated. To learn more, visit

For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.

UPMC is an equal opportunity employer. UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, gender identity, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.

Medical information made available on is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.

Pittsburgh, PA, USA |