Navigate Up

UPMC/University of Pittsburgh Schools of the Health Sciences
Patients and medical professionals may call 1-800-533-UPMC (8762) for more information.

Brain Studies Show Children From Alcoholic Families Are More Prone To Drink, Report University Of Pittsburgh Researchers

PITTSBURGH, June 5, 2001 — Researchers at the University of Pittsburgh have discovered that adolescents from families with a history of alcohol dependence have differences in their brains that make them prone to alcohol abuse before they ever touch a drink. The article was published in today’s issue of Biological Psychiatry.

The research team, headed by Shirley Y. Hill, Ph.D., professor of psychiatry, psychology and human genetics at the University of Pittsburgh School of Medicine, studied adolescents who averaged 17 years of age from families with multigenerational alcohol dependence to see if they had morphological changes in their brains that could make them susceptible to alcohol abuse.

Through brain imaging, Dr. Hill found changes in the amygdala, a walnut-sized structure in the brain that helps control basic emotions. Children from families with a history of abuse had reduced right amygdala volume compared with children from families with no abuse.

“The effect on the amygdala is significant because the amygdala is part of an important reward circuit that has been implicated in addictive behavior including cocaine use, gambling and now, familial alcohol dependence. This circuit is one of the fundamental components of the brain’s reward systems and appears to be important in the reinforcing actions of repeated drug and alcohol abuse,” explained Dr. Hill.

Why the right amygdala in particular is affected is not known, but perhaps a faster rate of growth in the right brain versus left brain during childhood and adolescence makes it more likely that developmental lags in growth in this area may show up more prominently on the right side.

“We suspect that brain development for some of the adolescents catches up by adulthood. Nevertheless, they are more vulnerable as teens. We have found in our studies that teens from families with a history of alcohol dependence begin drinking earlier. This pattern in such a vulnerable group of teens can set up a pathway toward alcohol dependence lasting into or even through adulthood,” said Dr. Hill.

“Additionally, there is evidence that the brains of teenagers may be more susceptible to the negative consequences of heavy alcohol consumption,” said Dr. Hill. “Our research shows that, in kids from families with a history of alcohol dependence, some of these changes actually appear before they start drinking, which points to a strong genetic influence.”

For the study, Dr. Hill’s team examined 34 adolescent and young adult male participants identified as high risk because of their strong family history. Of that group, 22 were part of a larger study begun in 1990 to study alcohol dependence. Because the researchers had been following them for about seven years, they had yearly evaluations from which to draw data.

The researchers used magnetic resonance imaging (MRI) to examine brain structure and calculated the average size of each group’s amygdalas. In addition to imaging, all subjects received a number of clinical evaluations to determine IQ, cognitive function and the presence of affective disorders such as depression or anxiety. This enabled the researchers to make sure that the high-risk group of adolescents from the multigenerational alcohol dependence families were well-matched to the control participants who did not have a family history of alcohol dependence.

Dr. Hill’s research was supported by the National Institute of Alcohol Abuse and Alcoholism.

UPMC | Affiliated with the University of Pittsburgh Schools of the Health Sciences Supplemental content provided by Healthwise, Incorporated. To learn more, visit

For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.

UPMC is an equal opportunity employer. UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, gender identity, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.

Medical information made available on is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.

Pittsburgh, PA, USA |