Navigate Up

UPMC/University of Pittsburgh Schools of the Health Sciences

Patients and medical professionals may call 1-800-533-UPMC (8762) for more information.

UPMC Recruiting for Advanced Heart Failure Clinical Trial

PITTSBURGH, November 10, 2008 — UPMC currently is enrolling for a Phase 2 clinical trial to study the effects of a genetically-targeted enzyme replacement therapy for advanced heart failure. Initial data for the study “Calcium Up-Regulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID trial)” were recently reported at the American Heart Association Scientific Sessions in New Orleans, La.

Potential candidates for the trial are patients who continue to deteriorate from their disease despite optimal drug therapy and who are eligible for either an implantable mechanical support device or a heart transplant.

Phase 2 of the study is a randomized, double-blind, placebo-controlled trial that compares the use of the enzyme replacement therapy at two- or three-dose levels with placebo. The therapy is delivered in a single dose directly to the heart muscle during a 10-minute outpatient procedure, performed in a cardiac catheterization laboratory via a small incision in the upper leg.  

The CUPID trial is expected to enroll 46 patients with advanced heart failure at 15 medical centers throughout the United States.

For more information, or to see if you qualify for the CUPID trial at UPMC, call 412-383-7339.

UPMC | Affiliated with the University of Pittsburgh Schools of the Health Sciences Supplemental content provided by Healthwise, Incorporated. To learn more, visit

For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.

UPMC is an equal opportunity employer. UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, gender identity, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.

Medical information made available on is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.

Pittsburgh, PA, USA |