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University of Pittsburgh Schools of the Health Sciences

Mark Gladwin, M.D., First University of Pittsburgh Faculty Member Elected to the Council of the American Society for Clinical Investigation

PITTSBURGH, May 17Mark Gladwin, M.D., chief, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, recently was elected to serve on the council of the American Society for Clinical Investigation (ASCI).

ASCI is one of the nation’s oldest and most respected medical honor societies. It comprises more than 2,800 physician scientists from all medical specialties and is dedicated to the advancement of research that extends understanding and improves treatment of human diseases. Members are elected to the Society for their outstanding records of scholarly achievement in biomedical research and commitment to mentoring future generations of physician scientists.

“I am delighted to have been chosen to serve as one of six councilors to the American Society for Clinical Investigation,” said Dr. Gladwin. “I’ve been a member since 2006 and am honored to receive this prestigious position within the Society.”

Dr. Gladwin currently is the principal investigator on the multi-center clinical trials Walk-PHASST (Pulmonary Hypertension and Sickle Sildenafil Therapy Trial) and DeNOVO (Delivery of NO for Vaso-Occlusive pain crisis in sickle cell disease). He has served as a principal or associate investigator on more than 25 clinical trials.

Since 1998, his research activities have led to more than 180 published, peer-reviewed manuscripts. Dr. Gladwin’s work includes the discovery that the nitrite anion is a regulator of blood pressure and blood flow and mediates hypoxic signaling. He also characterized the role of hemolytic anemia in driving vascular disease and pulmonary hypertension, which occurs in 30 percent of patients with the hemolytic anemia sickle cell disease, making it a major cause of mortality in this population.

“This is a great honor for both Dr. Gladwin and the School of Medicine,” said Arthur S. Levine, M.D., senior vice chancellor for the health sciences and dean, School of Medicine, University of Pittsburgh.

Dr. Gladwin received his medical degree from the University of Miami Honors Program in Medical Education in 1991. After completing his internship and chief residency at the Oregon Health Sciences University in Portland, he joined the National Institutes of Health (NIH) in 1995 as a critical care fellow. After completing a clinical fellowship in pulmonary medicine at the University of Washington in Seattle, Dr. Gladwin served as chief of the Pulmonary and Vascular Medicine Branch within the National Heart, Lung, and Blood Institute, an arm of the NIH. In August 2008, Dr. Gladwin became chief of the Pulmonary, Allergy and Critical Care Medicine Division at the University of Pittsburgh.

About the University of Pittsburgh School of Medicine

As one of the nation’s leading academic centers for biomedical research, the University of Pittsburgh School of Medicine integrates advanced technology with basic science across a broad range of disciplines in a continuous quest to harness the power of new knowledge and improve the human condition. Driven mainly by the School of Medicine and its affiliates, Pitt has ranked among the top 10 recipients of funding from the National Institutes of Health since 1997 and now ranks fifth in the nation, according to preliminary data for fiscal year 2008. Likewise, the School of Medicine is equally committed to advancing the quality and strength of its medical and graduate education programs, for which it is recognized as an innovative leader, and to training highly skilled, compassionate clinicians and creative scientists well-equipped to engage in world-class research. The School of Medicine is the academic partner of UPMC, which has collaborated with the University to raise the standard of medical excellence in Pittsburgh and to position health care as a driving force behind the region’s economy. For more information about the School of Medicine, see

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