Pentostatin: High-Dose for SCT (Generic Name)
Other Names: 2-deoxycoformycin
About This Drug
Pentostatin is used to treat cancer. This drug is given intravenously (IV).
Possible Side Effects
- Nausea and vomiting. These symptoms may occur within hours after you receive the drug.
- Drowsiness, difficulty in awakening
- Rash or dry skin
- Joint and muscle pain
- Sexual problems and reproduction concerns may occur. In men and women both, this drug may temporarily or permanently affect your ability to have children. This cannot be determined before your therapy. In men, this drug may interfere with your ability to make sperm, but it should not change your ability to have sexual relations. In women, menstrual bleeding may become irregular or stop while you are receiving this drug. Do not assume that you cannot become pregnant if you do not have a menstrual period. Women may experience signs of menopause like vaginal dryness or itching.
- This drug may have harmful effects on the unborn child, so effective methods of birth control should be used during your cancer treatment.
- Genetic counseling is available to you to discuss the effect of this drug therapy on future pregnancies. In addition, a genetic counselor can review the potential risks of problems in the fetus due to this medication if an exposure during pregnancy has occurred.
- Changes in kidney function. This drug may affect how your kidneys work. Your kidney function will be checked as needed.
- Eye pain or discomfort due to inflammation of the cornea and conjunctiva
Treating Side Effects
- Ask your doctor or nurse about medication that is available to help prevent or lessen nausea.
- Use effective methods of birth control during your cancer treatment.
- Vaginal lubricants can be used to lessen vaginal dryness, itching, and pain during sexual relations.
- Speak with your doctor or nurse if you plan to have children. Ask for information on sperm or egg banking.
Food and Drug Interactions
There are no known interactions of pentostatin and any food. This drug may interact with other medications. Tell your doctor and pharmacist all the medications that you are currently taking.
When to Call the Doctor
Call your doctor or nurse immediately if you have any of the following symptoms:
- Temperature of 100.5 F (38 C) or above
- Unusual bleeding or bruising
- Uncontrolled nausea that prevents you from eating or drinking
- Eye pain, redness, or swelling
- Difficulty in awakening, unusual drowsiness
Call your doctor or nurse as soon as possible if you have any of the following symptoms:
- Nausea unrelieved by prescribed medication
- Pain in your joints and muscles unrelieved by prescribed medication
- Decreased urination, in frequency and amount