About This Drug
Brigatinib is used to treat cancer. It is given orally (by mouth).
Possible Side Effects
- Loose bowel movements (diarrhea)
: Each of the side effects above was reported in 25% or greater of patients treated with brigatinib. Not all possible side effects are included above.
Warnings and Precautions
- Inflammation (swelling) of the lungs. You may have a dry cough or trouble breathing
- High blood pressure. Your doctor will check your blood pressure as needed.
- Decrease in heart rate may occur. Your doctor will monitor your heart rate as needed.
- Blurred vision or other changes in eyesight
- Muscle tissue injury, you may have unexplained muscle pain, tenderness or weakness
- Inflammation of your pancreas. Your doctor will check your pancreas function as needed
- Blood sugar levels may change. If you have diabetes, changes may need to be made to your diabetes medication.
How to Take Your Medicine
- Swallow the medicine whole with or without food. Do not chew, break or crush it.
- Missed dose: If you vomit or miss a dose, take your next dose at the regular time. Do not take 2 doses at the same time
- Handling: Wash your hands after handling your medicine, your caretakers should not handle your medicine with bare hands and should wear latex gloves.
- This drug is excreted in the urine, stool, vomit, semen, and vaginal secretions. Talk to your doctor and/or your nurse about the necessary precautions to take during this time.
- Storage: Store this medicine in the original container at room temperature. Discuss with your nurse or your doctor how to dispose of unused medicine
Treating Side Effects
- Drink plenty of fluids (a minimum of eight glasses per day is recommended).
- If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack water in the body from losing too much fluid).
- To help with nausea and vomiting, eat small, frequent meals instead of three large meals a day. Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help or stop lessen these symptoms.
- Manage tiredness by pacing your activities for the day. Be sure to include periods of rest between energy-draining activities
- Keeping your pain under control is important to your well-being. Please tell your doctor or nurse if you are experiencing pain.
- If you have diabetes, monitor your blood sugar level. Tell your nurse or your doctor if your glucose levels are higher or lower than normal.
Food and Drug Interaction
- Check with your doctor or pharmacist about all other prescription medicines and dietary supplements you are taking before starting this medicine as there are a lot of known drug interactions with brigatinib. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplement to make sure that there are no interactions.
- Do not eat grapefruit or drink grapefruit juice while taking this medicine. Grapefruit and grapefruit juice may raise the levels of brigatinib in your body. This could make side effects worse.
When to Call the Doctor
Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:
- Fever of 100.5 F (38 C) or higher
- Feeling dizzy or lightheaded
- Pain in your chest
- Dry cough
- Wheezing or trouble breathing
- A headache that does not go away
- Blurry vision or other changes in eyesight
- Nausea that stops you from eating or drinking, and/or is not relieved by prescribed medicines
- Loose bowel movements (diarrhea) 4 times a day or loose bowel movements with lack of strength or a feeling of being dizzy
- Fatigue that interferes with your daily activities
- Abnormal blood sugar
- Unusual thirst, passing urine often, headache, sweating, shakiness, irritability
- Unexplained muscle pain, tenderness or weakness
- If you think you may be pregnant or have impregnated your partner
Reproduction Warnings and Precautions
Infertility warning: In men, this drug may reduce your ability to make sperm, but it should not change your ability to have sexual relations. Genetic counseling may be available for you to talk about the effects of this drug therapy on future pregnancies.
Pregnancy warning: This drug can have harmful effects on the unborn baby. It is recommended
that effective methods of birth control should be used by both men and women during cancer treatment. Men with female partners who could become pregnant should use effective methods of birth control for at least 3 months after treatment. Women who could become pregnant should use a non-hormonal method of birth control during treatment and for at least 4 months after treatment. Birth control pills (oral contraceptives) may not be effective.
Breast feeding warning: Women should not breast feed during treatment and for 1 week after treatment because this drug could enter the breast milk and cause harm to a breast feeding baby.
Revised June 2017