Eltrombopag (Generic Name)

Other Names: Promacta®

About this Drug:

Eltrombopag is used to raise platelet counts. It is given by mouth.

Possible Side Effects (More Common)

  • Blood clots. A blood clot in your leg may cause your leg to swell, appear red and warm, and/or cause pain. A blood clot in your lungs may cause trouble breathing, pain when breathing, and/or chest pain.
  • Changes in your central nervous system can happen. The central nervous system is made up of your brain and spinal cord. You could feel extreme tiredness, agitation, confusion, hallucinations (see or hear things that are not there), trouble understanding or speaking, loss of control of your bowels or bladder, eyesight changes, numbness or lack of strength to your arms, legs, face, or body, and coma. If you start to have any of these symptoms let your doctor know right away.
  • Loose bowel movements (diarrhea) that may last for a few days.
  • Decreased appetite (decreased hunger)
  • Generalized weakness and discomfort (aches or pains)
  • This drug may raise your risk of getting a second cancer.
  • Nerve, muscles or joint pain
  • Cataract (clouding of the lens in your eye) formation: this drug may make cataracts worse or may raise the chance of new cataracts. Talk with your doctor if you experience any of these symptoms in your eye.
  • Changes in your liver function. This may be worse if you have Hepatitis C. Your doctor will check your liver function as needed.

Possible Side Effects (Less Common)

  • Swelling of your legs, ankles and/or feet
  • Urinary tract infection. Symptoms may include: pain or burning when you pass urine, feeling like you have to pass urine often, but not much comes out when you do, tender or heavy feeling in your lower abdomen, cloudy urine and/or urine that smells bad. Pain on one side of your back under your ribs (this is where your kidneys are).

Treating Side Effects

  • Drink 6-8 cups of fluids each day unless your doctor has told you to limit your fluid intake due to some other health problem. A cup is 8 ounces of fluid. If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack of water in the body from losing too much fluid).
  • Ask your doctor or nurse about medicine that is available to help stop or lessen the loose bowel movements.
  • If you are dizzy, get up slowly after sitting or lying.
  • If you get symptoms of a bladder infection, please call your doctor or nurse right away. You may be given antibiotics to treat the infection and/or medicines to help the symptoms.

How is this drug taken?

All products:

  • Take on an empty stomach. Take 1 hour before or 2 hours after meals.
  • Take this drug at least 2 hours before or 4 hours after any antacids; dairy products or other foods with calcium in them; or products that have calcium, iron, aluminum, magnesium, selenium, or zinc.
  • Store this medicine in the original container at room temperature.
  • If you vomit or miss a dose, take your next dose at the regular time. Do not take 2 doses at the same time.

Tablets:

  • Swallow whole. Do not chew, break, or crush.

Powder for suspension:

  • Before using, be sure you know how to mix and measure the dose of this drug. Talk with the doctor or pharmacist if you are not sure.
  • Mix powder with water only as you have been told.
  • Do not use hot water to mix this drug.
  • Take your dose within 30 minutes after mixing. Throw away any part not used within 30 minutes of mixing.

Food and Drug Interactions

Check with your doctor or pharmacist about all other prescription medicines and dietary supplements you are taking before starting this medicine as there are a lot of known drug interactions with eltrombopag. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplement to make sure that there are no interactions.

When to Call the Doctor

Call your doctor or nurse immediately if you have any of the following symptoms:

  • Allergic reactions to this drug are rare, but may happen in some patients. Signs of allergic reactions to this drug may be a rash, fever, chills, feeling dizzy, trouble breathing, and/or feeling that your heart is beating in a fast or not normal way
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Loose bowel movements (diarrhea) 4 times or loose bowel movements with lack of strength or a feeling of being dizzy
  • Fever of 100.5 F (38 C) or higher
  • Chills
  • Easy bleeding or bruising
  • Wheezing or trouble breathing
  • Rash or itching
  • Feeling dizzy or lightheaded
  • Nausea that stops you from eating or drinking

Call your doctor or nurse as soon as possible if any of the following symptoms occur:

  • Decreased urine
  • Blurred vision or other changes in eyesight
  • Rash that is not relieved by prescribed medicines
  • Swelling of legs, ankles, or feet
  • Weight gain of 5 pounds in one week (fluid retention)
  • Fatigue that interferes with your daily activities
  • Extreme weakness that interferes with normal activities

Reproduction Concerns

  • Pregnancy warning: It is not known if this drug may harm an unborn child. For this reason, be sure to talk with your doctor if you are pregnant or planning to become pregnant while getting this drug.
  • Breast feeding warning: It is not known if this drug passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breast feeding during treatment with this drug because this drug may enter the breast milk and badly harm a breast feeding baby.

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