Vandetanib (Generic Name)

Other Names: Caprelsa®

About This Drug

Cabazitaxel is a drug used to treat cancer. This drug is given by mouth

Possible Side Effects (More Common)

  • Nausea and throwing up (vomiting)
  • Bone marrow depression. This is a decrease in the number of white blood cells, red blood cells, and platelets. This may raise your risk of infection, make you tired and weak (fatigue), and raise your risk of bleeding.
  • Loose bowel movements (diarrhea)
  • Abdominal pain
  • High blood pressure
  • Cough
  • Headache
  • Decrease in appetite
  • Fatigue
  • Weakness
  • Skin changes such as a rash which may look like acne, redness, itchiness, dry skin or cracked skin, peeling skin or signs of skin infection.
  • Trouble sleeping
  • Depression
  • Blurred vision
  • Changes in your heart, liver, kidney function. Your doctor will check this by doing blood tests.
  • Changes in your electrolytes which will be checked by blood tests.

Possible Side Effects (Less Common)

  • Lung infection
  • Your heart tissue can be harmed. This may cause your heart to beat in a way that is not normal. Your doctor may order an EKG to check this.
  • Trouble breathing. Call 911 if there is severe shortness of breath or lack of breathing
  • Hand and foot syndrome. The palms of your hands or soles of your feet may tingle, become numb, painful, swollen, or red.
  • Soreness of the mouth and throat. You may have red areas, white patches, or sores that hurt.
  • Allergic reactions, including anaphylaxis are rare but may happen in some patients. Signs of allergic reactions to this drug may be swelling of the face, feeling like your tongue or throat are swelling, trouble breathing, rash, itching, fever, chills, feeling dizzy, and/or feeling that your heart is beating in a fast or not normal way. If this happens, do not take another dose of this drug. You should get urgent medical treatment.

Treating Side Effects

  • Drink 6-8 cups of fluids each day unless your doctor has told you to limit your fluid intake due to some other health problem. A cup is 8 ounces of fluid. If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack water in the body from losing too much fluid).
  • Ask your doctor or nurse what you can put on a rash or other skin problem. Do not put anything on a rash or skin redness unless your doctor or nurse says you may. Keep the area around the rash clean and dry.
  • Mouth care is very important. Your mouth care should consist of regular, gentle cleaning of your teeth or dentures and rinsing your mouth with a mixture of ½ teaspoon of salt in 8 ounces of water or 1/2 teaspoon of sodium bicarbonate (baking soda) in 8 ounces of water.
  • Avoid mouthwash that contains alcohol. Avoid alcohol and smoking because they can irritate your mouth and throat.
  • Ask your doctor or nurse about medicine to help stop or lessen nausea, throwing up, stomach or abdominal pain, headache and/or loose bowel movements.

Food and Drug Interactions

There are known interactions of Vandetanib with some other medicines and food. Ask your doctor what over-the-counter (OTC) medicines you can take for fever, headache and muscle and joint pain. Do not eat grapefruit or drink grapefruit juice.

Talk with your doctor about taking St. John’s Wort, garlic, ginseng, and ginkgo. Tell your doctor and pharmacist about all the medicines and dietary supplements (vitamins, minerals, herbs and others) that you are taking at this time. The safety and use of dietary supplements and alternative diets are often not known. Using these might affect your cancer or interfere with your treatment. Until more is known, you should not use dietary supplements or alternative diets without your cancer doctor's help.

When to Call the Doctor

Call your doctor or nurse right away if you have any of these symptoms:

  • Fever of 100.5 F (38 C) or above
  • Chills
  • Rash, sores, reddened areas or itching that is not relieved by prescribed medicines
  • Easy bruising or bleeding
  • Chest pain. Call 911 if symptoms last 2 minutes or longer
  • Trouble breathing or pain when breathing. Call 911 if there you have severe shortness of breath or lack of breathing
  • Seizure
  • Severe headache
  • Sudden trouble seeing in one or both eyes.
  • Sudden trouble walking, dizziness, or loss of balance or coordination
  • Trouble speaking or confusion
  • Nausea that stops you from eating or drinking
  • Throwing up more than 3 times in one day
  • Loose bowel movements (diarrhea) more than 3 times a day, or diarrhea with weakness or feeling lightheaded
  • Severe swelling of your arms, hands, legs or feet

Call your doctor or nurse as soon as possible if you have any of these symptoms:

  • Numbness or tingling of your palms or soles of your feet, if they become painful, swollen or develop blisters.
  • Swelling in your legs, ankles or feet
  • Swollen, red, warm or painful leg
  • No bowel movement for 3 days or if you feel uncomfortable
  • Pain, nausea, throwing up, or loose bowel movements that are not relieved by prescribed medicines.
  • Lasting loss of appetite or weight loss of 5 pounds or more
  • Extreme fatigue or weakness that interferes with daily activities.
  • Weight gain of more than 5 pounds in a week
  • Pain in your mouth or throat that makes it hard to eat or drink

Reproductive Concerns

  • Pregnancy warning: This drug may have harmful effects on the unborn child, so effective methods of birth control should be used during your cancer treatment.
  • Genetic counseling is available for you to talk about the effects of this drug therapy on future pregnancies. Also, a genetic counselor can look at the possible risk of problems in the unborn baby due to this medicine if an exposure happens during pregnancy.
  • Breast feeding warning: It is not known if this drug passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breast feeding during treatment with this drug because this drug may enter the breast milk and badly harm a breast feeding baby.

Revised July 2014

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