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Heart and Vascular Clinical Trials

Clinical trials are research studies involving human volunteers who are closely monitored by:

  • Doctors
  • Nurses
  • Research assistants
  • Data analysts

If you are considering participation in a clinical trial, it is important to:

  • Discuss your health and review your medical records with your cardiologist and care team to determine eligibility.
  • Ask your cardiologist to assist you in discussing the decision with family members and caregivers, so questions or concerns can be addressed.
  • Work with your doctor to sign and consent to trial treatment.
  • Remember that participation is voluntary. You may choose to or be asked to cease participation in the trial at any time.

» Search the US government's clinical trial database now for heart and vascular trials.

Featured Clinical Trials and Research

REVIVE-IT - Artificial Heart Research Study

​Who can participate ​100 patients were chosen from select US hospitals, including UPMC and University of Michigan
​What we'll study The National Heart, Lung, and Blood Institute and HeartWare®, a maker of left ventricular assist devices (LVADs), are sponsoring the study of earlier access to devices that support the circulation of patients with failing hearts. In REVIVE-IT, researchers will compare whether non-transplant eligible patients with heart failure less advanced than that of current LVAD recipients do better with implanted devices than with current medical therapy.

REVIVE-IT will study HeartWare’s battery-operated continuous blood flow pump that’s surgically placed within the heart and the pericardial space surrounding the heart.
​How we'll conduct the study

​REVIVE-IT is a two-part study consisting of a trial and a registry. 

The trial looks at evaluating the HeartMate II LVAS versus a control group consisting of optimal medical management. Patients will go through a series of screening visits to ensure they meet all study criteria. Once they pass the screening levels patients will be randomized (1:1) ratio to receive the HeartMate II LVAS implant or be managed with optimal medical therapy. 

They will be followed for study purposes for approximately 2 years. If a patient fails any of the screening visits he/she will be entered into the registry where information will be collected every 6 months related to their heart failure symptoms and how it is affecting their lives. These patients will be followed for approximately 2-5 years.

​Who to contact ​To learn more about this study or about participating in future clinical trials, please contact Jess Pisarcik at
412-647-4463.

 

Evaluation of the GORE TAG Thoracic Branch Endoprosthesis of in the Treatment of Proximal Descending Thoracic Aortic Aneurysms (SSB 11-02, investigational device)

Who can participate Patients with thoracic aortic aneurysms
What we'll study

The SSB 11-02 device treats thoracic aortic aneurysms, which generally occur in the elderly and can lead to a life-threatening rupture of the aorta, the largest artery in the body. Designed to seal-off a hard-to-treat section of the aorta, the device potentially provides a safe and less invasive alternative to open heart surgery.

Through thoracic branch technology and design, this device fits the unique characteristics of the descending aorta, allowing physicians to treat a subset of patients that could not be considered for total endovascular repair in the past.

Endovascular repair uses real-time x-ray and guidewires to help deliver a graft, inserted via catheter, to exclude the lesion inside the diseased aorta, making a new path for blood to flow. Through this less invasive technique, physicians can treat conditions through small incisions in the groin that might otherwise require open chest surgery.

It is hoped that the utilization of this device will reduce the need for invasive surgical procedures commonly required today, thus reducing the complications associated with treatment of this complex disease.

Who to contact To learn more about this study or about participating in future clinical trials, please contact the Division of Vascular Surgery by calling 1-855-UPMC-HVI (option 2) or email us at VascularSurgeryResearch@upmc.edu

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