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Heart and Vascular Clinical Trials

Clinical trials are research studies involving human volunteers who are closely monitored by:

  • Doctors
  • Nurses
  • Research assistants
  • Data analysts

If you are considering participation in a clinical trial, it is important to:

  • Discuss your health and review your medical records with your cardiologist and care team to determine eligibility.
  • Ask your cardiologist to assist you in discussing the decision with family members and caregivers, so questions or concerns can be addressed.
  • Work with your doctor to sign and consent to trial treatment.
  • Remember that participation is voluntary. You may choose to or be asked to cease participation in the trial at any time.

» Search the US government's clinical trial database now for heart and vascular trials.

Featured Clinical Trials and Research

REVIVE-IT - Artificial Heart Research Study

​Who can participate ​100 patients were chosen from select US hospitals, including UPMC and University of Michigan
​What we'll study The National Heart, Lung, and Blood Institute and HeartWare®, a maker of left ventricular assist devices (LVADs), are sponsoring the study of earlier access to devices that support the circulation of patients with failing hearts. In REVIVE-IT, researchers will compare whether non-transplant eligible patients with heart failure less advanced than that of current LVAD recipients do better with implanted devices than with current medical therapy.

REVIVE-IT will study HeartWare’s battery-operated continuous blood flow pump that’s surgically placed within the heart and the pericardial space surrounding the heart.
​How we'll conduct the study

​REVIVE-IT is a two-part study consisting of a trial and a registry. 

The trial looks at evaluating the HeartMate II LVAS versus a control group consisting of optimal medical management. Patients will go through a series of screening visits to ensure they meet all study criteria. Once they pass the screening levels patients will be randomized (1:1) ratio to receive the HeartMate II LVAS implant or be managed with optimal medical therapy. 

They will be followed for study purposes for approximately 2 years. If a patient fails any of the screening visits he/she will be entered into the registry where information will be collected every 6 months related to their heart failure symptoms and how it is affecting their lives. These patients will be followed for approximately 2-5 years.

​Who to contact ​To learn more about this study or about participating in future clinical trials, please contact Jess Pisarcik at
412-647-4463.

 

ATTRACT - Vascular Surgery Research Study

​Who can participate ​Patients with lower extremity deep vein thrombosis (DVT)
​What we'll study

​The NIH/NHLBI-sponsored study will determine if clot-busting treatments should be routinely used in patients with lower extremity deep vein thrombosis (DVT).

Visit the study website now to learn more.

​How we'll conduct the study

​If you agree to participate in the study:

  • Staff will review your medical records, ask about your health, perform a physical exam, measure your leg and record any leg pain that you have.
  • You will be asked to have a small amount of blood taken as well as complete a questionnaire. You will return for visits at 10 days and one month after initial treatment and then every six months for two years.
  • You will be reimbursed up to a total of $100 for time and travel involved in coming to follow-up visits and completion of research questionnaires.
​Who to contact ​To learn more about this study or participating in future clinical trials, please contact Kevin Stiegler at
412-623-8452 or Mike Iskoe at 412-623-3333.

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