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​​Lanreotide (Generic Name) Other Names: Somatuline® Depot


UPMC Content 2

About This Drug

Lanreotide is used to treat cancer. It is given as a deep subcutaneous (below the skin) injection into the buttock.

Possible Side Effects (More Common)

  • Pain in the abdomen, gas (flatulence)
  • Muscle aches
  • Headache
  • Nausea and throwing up (vomiting)
  • Loose bowel movements (diarrhea) that may last for a few days
  • Pain at the site of injection
  • High blood pressure. Your doctor will check your blood pressure as needed
  • Decrease in heart rate may occur. Your doctor will monitor your heart rate as needed
  • Blood sugar levels may change– monitor blood sugar levels at start of treatment and with dose changes. Changes may need to be made to your diabetes medication.
  • This drug may affect how your gall bladder works. You may develop gallstones.

Possible Side Effects (Less Common)

  • Constipation (not able to move bowels)
  • Feeling dizzy
  • Changes in your thyroid function. Your doctor will monitor your thyroid function as needed.

Allergic Reactions

Allergic reactions, including anaphylaxis are rare but may happen in some patients. Signs of allergic reaction to this drug may be swelling of the face, feeling like your tongue or throat are swelling, trouble breathing, rash, itching, fever, chills, feeling dizzy, and/or feeling that your heart is beating in a fast or not normal way. If this happens, do not take another dose of this drug. You should get urgent medical treatment.

Treating Side Effects

  • Drink 6-8 cups of fluids each day unless your doctor has told you to limit your fluid intake due to some other health problem. A cup is 8 ounces of fluid. If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack water in the body from losing too much fluid).
  • If you are dizzy, get up slowly after sitting or lying down
  • Ask your doctor or nurse about medicines that are available to help stop or lessen diarrhea or constipation.

Food and Drug Interactions

There are no known interactions of lanreotide with food. This drug may interact with other medicines. Tell your doctor and pharmacist about all the medicines and dietary supplements (vitamins, minerals, herbs and others) that you are taking at this time. The safety and use of dietary supplements and alternative diets are often not known. Using these might affect your cancer or interfere with your treatment. Until more is known, you should not use dietary supplements or alternative diets without your cancer doctor's help.

When to Call the Doctor

  • Loose bowel movements (diarrhea) 4 times or loose bowel movements with lack of strength or a feeling of being dizzy
  • Fever of 100.5 F (38 C) or higher
  • Chills
  • Wheezing or trouble breathing
  • Rash or itching
  • Feeling dizzy or lightheaded
  • Nausea that stops you from eating or drinking
  • Throwing up more than 3 times a day
  • No bowel movement for 3 days or if you feel uncomfortable
  • Bad abdominal pain, especially in upper right area
  • Pain between shoulder blades, or in right shoulder
  • Abnormal blood sugar
  • Unusual thirst, passing urine often, headache, sweating, shakiness, irritability
  • Feeling that heart is beating too slow or too fast

Reproduction Concerns

  • Pregnancy warning: It is not known if this drug may harm an unborn child. For this reason, be sure to talk with your doctor if you are pregnant or planning to become pregnant while getting this drug.
  • Breast feeding warning: It is not known if this drug passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breast feeding during treatment with this drug because this drug may enter the breast milk and badly harm a breast feeding baby.

New Drug Sheets: November 2016

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