About This Drug
Panobinostat is used to treat cancer. It is given by mouth.
Possible Side Effects (More Common)
- Your heart tissue can be harmed. This may cause your heart to beat in a way that is not normal. You doctor may order an EKG to check this before you start treatment and while receiving treatment
- Loose bowel movements (diarrhea) that may last for a few days
- Nausea and throwing up (vomiting). Medicines are available to stop or lessen these side effects.
- Bone marrow depression. This is a decrease in the number of white blood cells, red blood cells, and platelets. This may raise your risk of infection, make you tired and weak (fatigue), and raise your risk of bleeding.
- Increased total bilirubin in your blood. This may mean that you have changes in your liver function. Your blood work will be checked by your doctor.
- Electrolyte changes. Your blood will be checked for electrolyte changes as needed.
Possible Side Effects (Less Common)
- This drug may affect how your kidneys work. Your kidney function will be checked as needed.
Allergic reactions to this drug are rare, but may happen in some patients. Signs of allergic reactions to this drug may be a rash, fever, chills, feeling dizzy, trouble breathing, and/or feeling that your heart is beating in a fast or not normal way. If you have any of these symptoms do not take another dose of this drug. You should get urgent medical treatment.
Treating Side Effects
- Drink 6-8 cups of fluids each day unless your doctor has told you to limit your fluid intake due to some other health problem. A cup is 8 ounces of fluid. If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack water in the body from losing too much fluid).
- Ask your doctor or nurse about medicine that is available to help stop or lessen the loose bowel movements.
- If you get a rash do not put anything on it unless your doctor or nurse says you may. Keep the area around the rash clean and dry. Ask your doctor for medicine if the rash bothers you.
You can take the medicine with or without food. If you have nausea, take it with food.
- Swallow the medicine whole. Do not chew, break, or crush it.
- Avoid touching the powder in these capsules. If you accidentally get powder from the capsule on your skin, wash the area with soap and water. If you accidentally get powder from the capsule in your eyes, flush your eyes with water.
- Take this medicine at the same time each day
- Store this medicine in the original container at room temperature
- Consider taking a medicine to lessen nausea before you take this drug
- Missed dose: If you miss a dose of panobinostat, take it as soon possible, up to 12 hours after the time the dose should have been taken.
Food and Drug Interactions
- There are known interactions of panobinostat with grapefruit, star fruit, and pomegranate. Do not eat grapefruit, star fruit, or pomegranate and do not drink grapefruit or pomegranate juice while taking this drug.
- Check with your doctor or pharmacist about all other prescription medicines and dietary supplements you are taking before starting this medicine as there are a lot of known drug interactions panobinostat. Also, check with your doctor of pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplement to make sure that there are no interactions.
When to Call the Doctor
Call your doctor or nurse right away if you have any of these symptoms:
- Chest pain or symptoms of heart attack. Most heart attacks involve pain in the center of the chest that lasts more than a few minutes. The pain may go away and come back or it can constant. It can feel like pressure, squeezing, fullness, or pain. Sometimes pain is felt in one or both arms, the back, neck, jaw, or stomach. If any of these symptoms last 2 minutes, call 911.
- Loose bowel movements (diarrhea) 4 times or loose bowel movements with lack of strength or a feeling of being dizzy
- Fever of 100.4 F (38 C) or higher
- Easy bleeding or bruising
- Feeling dizzy or lightheaded
- Feeling that your heart is beating in a fast or not normal way (palpitations)
- Feeling confused or agitated
- Nausea that stops you from eating or drinking
- Throwing up more than 3 times a day
- Signs of liver problems: dark urine, pale bowel movements, bad stomach pain, feeling very tired and weak, unusual itching, or yellowing of the eyes or skin
Call your doctor or nurse as soon as possible if any of these symptoms happen:
- Decreased urine
- Nausea that is not relieved by prescribed medicines
- Fatigue that interferes with your daily activities
- Pregnancy warning: this drug may cause very harmful effects on an unborn child. Panobinostat should never be used by woman who are pregnant or who could become pregnant while taking the drug. Even 1 dose taken by a pregnant woman can cause these very harmful effects. Effective methods of birth control should be used by both men and women during your cancer treatment and for at least 3 months after treatment.
- Breast feeding warning: It is not known if this drug passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breast feeding during treatment with this drug because this drug may enter the breast milk and badly harm a breast feeding baby.
New Education Sheet: May 2015