About This Drug
Romidepsin is used to treat cancer. This drug is given in the vein (IV).
Possible Side Effects (More Common)
- Nausea and throwing up (vomiting). These symptoms may happen within a few hours of your treatment and may last up to 24 hours. Medicines are available to stop or lessen these side effects.
- Weakness and tiredness
- Decreased appetite (decreased hunger)
- Bone marrow depression. This is a decrease in the number of white blood cells, red blood cells, and platelets. This may raise your risk of infection, make you tired and weak (fatigue), and raise your risk of bleeding.
Possible Side Effects (Less Common)
- Constipation (not able to move bowels)
- Electrolyte changes. Your blood will be checked for electrolyte changes as needed.
- Your heart tissue can be harmed. This may cause your heart to beat in a way that is not normal. Your doctor may order an EKG to check this.
- Changes in your liver function. Your doctor will check your liver function as needed.
- Tumor lysis: This drug may act on the cancer cells very quickly. This may affect how your kidneys work. Your doctor will monitor your kidney function.
Treating Side Effects
- Drink 6-8 cups of fluids each day unless your doctor has told you to limit your fluid intake due to some other health problem. A cup is 8 ounces of fluid. If you throw up or have loose bowel movements you should drink more fluids so that you do not become dehydrated (lack water in the body due to losing too much fluid).
- Ask your doctor or nurse about medicines that are available to help stop or lessen constipation.
Food and Drug Interactions
- Avoid grapefruit and grapefruit juice as it may affect the levels of romidepsin in your body.
- This drug may interact with other medicines. Tell your doctor and pharmacist about all the medicines and dietary supplements (vitamins, minerals, herbs and others) that you are taking at this time. The safety and use of dietary supplements and alternative diets are often not known. Using these might affect your cancer or interfere with your treatment. Until more is known, you should not use dietary supplements or alternative diets without your cancer doctor's help.
When to Call Your Doctor
Call your doctor or nurse right away if you have any of these symptoms:
- Fever of 100.5 F (38 C) or higher
- Easy bleeding or bruising
- Feeling dizzy or lightheaded
- Feeling that your heart is beating in a fast or not normal way (palpitations)
- Nausea that stops you from eating or drinking
- Throwing up more than 3 times a day
- Signs of liver problems: dark urine, pale bowel movements, bad stomach pain, feeling very tired and weak, unusual itching, or yellowing of the eyes or skin.
Call your doctor or nurse as soon as possible if you have any of these symptoms:
- Nausea that is not relieved by prescribed medicines
- Lasting loss of appetite or rapid weight loss of five pounds in a week
- Fatigue that interferes with your daily activities
- Headache that does not go away
- No bowel movement for 3 days or you feel uncomfortable
- Extreme weakness that interferes with normal activities
- Pregnancy warning: This drug may have harmful effects on the unborn child, so effective methods of birth control should be used during your cancer treatment.
- Breast feeding warning: It is not known if this drug passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breast feeding during treatment with this drug because this drug may enter the breast milk and badly harm a breast feeding baby.
Revised November 2014