Also part of the UPMC family:
Also part of the UPMC family:

​Pitt Study of Early Onset Menopausal Symptoms Could Predict Heart Disease

For Journalists

Ashley Trentrock
Manager
412-586-9776
trentrockar@upmc.edu

Amy Charley
Manager
412-586-9778
charleya@upmc.edu

Want to Make an Appointment or Need Patient Information?
Contact UPMC at

1-800-533-UPMC (8762).

Go to Find a Doctor to search for a UPMC doctor.



9/28/2016

Main Content
PITTSBURGH, Sept. 28, 2016 – Women who experience hot flashes and night sweats earlier in life are more likely to die from cardiovascular disease (CVD) when compared to women with later onset menopausal symptoms, according to research from the University of Pittsburgh School of Medicine published today in the journal, Menopause.
 
Up to 80 percent of women experience menopausal symptoms, particularly hot flashes and night sweats, at some point during the menopause transition, said Rebecca Thurston, Ph.D., professor of psychiatry, Pitt School of Medicine.
 
“We used to think these were annoying symptoms that persist for several years around the final menstrual period and simply affect the quality of life for many women,” she said. “However, we now know that these symptoms persist far longer and often start earlier than we previously thought. Our research also suggests that for some women, particularly for younger midlife women, menopausal symptoms might mark adverse changes in the blood vessels during midlife that place them at increased risk for heart disease.”
 
The research indicates that early onset of menopausal symptoms is associated with dysfunction of the endothelium, which is the lining of blood vessels. Endothelial dysfunction was measured by assessing flow-mediated dilation (FMD), a noninvasive ultrasound measure of how well the vessel dilates in response to pressure on the wall of the blood vessel.
 
Dr. Thurston and her colleagues investigated associations between menopausal symptoms and risk for CVD complications among postmenopausal women participating in the National Heart, Lung, and Blood Institute Women’s Ischemia Syndrome Evaluation study. A total of 254 postmenopausal women with signs and symptoms of ischemic heart disease were evaluated, and researchers found those who had hot flashes before age 42 to be more likely to have lower FMD, suggesting adverse endothelial changes, as well as higher mortality from heart disease.
 
“While more work needs to be done to confirm our findings, our research could, one day, help us predict the midlife women who might be at increased risk for cardiovascular disease so that we proactively target these women for early prevention strategies,” Dr. Thurston said.
Find a Doctor

Browse UPMC doctors and medical professionals to find the care that's right for you. Customize your search by specialty, zip code, last name, and more.


Visit the UPMC Find a Doctor website.
Make an Appointment

Find important information on scheduling your appointment or finding a doctor or service that meets your needs.


Request an appointment now.
Find a Location

Browse addresses and contact information for our network of hospitals, specialty care practices, and community health locations.


Find a UPMC location near you.
Pay Your Bill

Learn more about how to pay your UPMC bill. Find resources including payment methods and contact information for assistance.


Pay your bill now.
Find a Career

Advance your career with UPMC. Discover our latest job listings and learn about our values and career pathways.


Find your ideal career at UPMC.