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Dr. Beth Roman's research lab is using a zebrafish model of HHT to find out how arteriovenous malformations (AVMs) form.
Her zebrafish model has a mutation in the ACVRL1 gene, the gene found in people with HHT2. The Zebrafish embryos that carry two mutated copies of this gene form AVMs during embryonic development.
The ACVRL1 gene encodes ALK1 protein.
Dr. Roman’s work focuses on:
For the latest information on HHT clinical trials, please visit ClinicalTrials.gov.
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