Also part of the UPMC family:
Also part of the UPMC family:

Research at the HHT Center of Excellence of UPMC and the University of Pittsburgh

UPMC Content 3

Zebrafish Model of HHT

Dr. Beth Roman's research lab is using a zebrafish model of HHT to find out how arteriovenous malformations (AVMs) form.

Her zebrafish model has a mutation in the ACVRL1 gene, the gene found in people with HHT2. The Zebrafish embryos that carry two mutated copies of this gene form AVMs during embryonic development.

The ACVRL1 gene encodes ALK1 protein.

Dr. Roman’s work focuses on:

  • Understanding the function of ALK1 protein within the cells that line blood vessels.
  • Defining the errors that these cells make that ultimately give rise to AVMs.

Learn more about HHT research at the University of Pittsburgh's HHT website.

Clinical Research Efforts

For the latest information on HHT clinical trials, please visit ClinicalTrials.gov.

Find a Doctor

Browse UPMC doctors and medical professionals to find the care that's right for you. Customize your search by specialty, zip code, last name, and more.


Visit the UPMC Find a Doctor website.
Make an Appointment

Find important information on scheduling your appointment or finding a doctor or service that meets your needs.


Request an appointment now.
Find a Location

Browse addresses and contact information for our network of hospitals, specialty care practices, and community health locations.


Find a UPMC location near you.
Pay Your Bill

Learn more about how to pay your UPMC bill. Find resources including payment methods and contact information for assistance.


Pay your bill now.
Find a Career

Advance your career with UPMC. Discover our latest job listings and learn about our values and career pathways.


Find your ideal career at UPMC.