What Are SAIDs?
SAIDs are rare diseases that affect your immune system.
They happen when a gene's DNA sequence changes and causes your immune system to not function the right way. This triggers inflammation in healthy tissue.
Inflammation is your body's response to an irritant or invader, like bacteria or a virus. Your immune system sends white blood cells and immune cells to attack and fight it off.
When you're sick or injured, inflammation may cause a fever, pain, or swelling as part of the healing process.
With a SAID, the inflammation happens for no reason, causing a widespread inflammatory response.
Symptoms often cause:
- Fever.
- Rashes.
- Pain in your joints, muscles, stomach, or other areas.
The symptoms come and go but tend to appear again in the same pattern.
What are the types of SAIDs?
There are more than 50 known SAIDs, often diagnosed in children.
Each SAID type has its own course. Some SAIDs go away on their own in a few years without issues. With others, chronic inflammation can lead to long-term effects if you don't manage it.
While all are rare, this autoinflammatory diseases list includes some of the more commonly known types:
- Cryopyrinopathies (Familial cold autoinflammatory syndrome (FCAS), Muckle Wells Syndrome (MWS), and Neonatal onset multisystem inflammatory disease (NOMID). This family of diseases can affect the skin, joints, eyes, and central nervous system. They usually start when you're an infant or in early childhood. Symptoms can include rash (often hive-like), fever, joint pain, meningitis, hearing loss, and inflammation. Symptoms may be triggered when you're exposed to cold temperatures.
- Familial Mediterranean fever (FMF). One of the most common genetic SAIDs, it tends to affect people of Mediterranean descent and starts in childhood. FMF causes chronic fevers, chest and belly pain, and skin rashes lasting one to three days.
- Haploinsufficiency of A20 (HA20). An autoinflammatory and autoimmune disease where patients typically develop oral and genital ulcers in combination with inflammation of the skin, joints, eyes, liver, kidneys, and/or brain. This is an inherited syndrome; often multiple family members are affected.
- Periodic fevers, cervical adenitis, pharyngitis, and aphthous stomatitis (PFAPA). The most common SAID in young children, it causes fevers with swollen lymph nodes, mouth sores, and a sore throat. These may last for days and recur every six weeks. PFAPA may go away on its own after a number of years.
- Schnitzler syndrome. This syndrome starts in adults in midlife and often affects men more than women. Symptoms include a hive-like rash and a fever that recurs.
- Tumor necrosis factor receptor-associated periodic syndrome (TRAPS). This syndrome causes a high fever that lasts for weeks. Other symptoms include a skin rash, severe stomach, chest, or joint pain, and swelling in or around the eyes.
- Systemic Juvenile Idiopathic Arthritis (sJIA) or Adult Onset Still Disease (AOSD). These syndromes typically present with daily episodes of high fevers, joint pain, lymph node swelling, and rash. In some cases, patients may develop cytokine storm syndrome that requires hospitalization.
- Vacuoles, E1 ligase, X-linked, Autoinflammatory, Somatic (VEXAS). This disease typically affects men over the age of 50 and combines some features of myelodysplastic syndrome (anemia, low platelet count, and low white blood cell count) with autoinflammation (rashes, inflammation of the nose/ear cartilage, fevers, and lung inflammation).
What causes autoinflammatory diseases?
Many SAIDs happen when a gene changes or mutates, which then affects how your innate immune system works.
A parent can pass a changed gene to a child. Genetic changes can also happen later in life after you're exposed to something in your setting or an illness.
Sometimes, doctors aren't sure what causes SAIDs.
What are SAID risk factors and complications?
The main risk factor is a family history. You may have a higher risk if your parents or siblings have a SAID. However, some patients develop SAIDs without a family history.
SAID complications may include:
- Amyloidosis (buildup of a protein that can damage organs).
- An enlarged liver or spleen.
- Arthritis.
- Hearing problems.
- Inflammation in your heart, lungs, or brain.
- Infertility (if amyloidosis does damage to reproductive organs).
- Kidney damage.
- Vision problems.
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Autoinflammatory Diseases Symptoms and Diagnosis
What are the signs and symptoms of SAIDs?
Each SAID has a unique pattern of symptoms that appear during a flare and often go away between flares.
Some of the more common signs and symptoms of SAIDs include:
- Belly pain, diarrhea, vomiting, and other symptoms in the stomach or intestines.
- Fevers (most often higher than 100.4 F).
- Fluid or inflammation around the heart or lungs.
- Mouth or genital sores.
- Painful or swollen joints or body aches.
- Rashes.
- Red eyes or inflammation inside or around the eyes.
- Sore throat with inflamed tonsils.
- Swollen lymph nodes.
How do you diagnose SAIDs?
To diagnose a SAID, doctors must rule out other health problems, like infections, that have common symptoms.
To find out if you have a SAID, your doctor may:
- Ask about your symptoms and any patterns.
- Look at your family history.
- Do an exam to check your skin, joints, and other affected parts of your body.
- Do bloodwork to check your white blood cells and inflammatory markers in your blood.
- Order genetic testing.
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What Are the Treatment Options for Autoinflammatory Diseases?
With proper monitoring and treatment, many people with SAIDs can live active and healthy lives.
SAIDs are complex, but UPMC provides complete and custom care.
Some SAIDs will get better with time.
Medicine and lifestyle changes can help manage symptoms and decrease the long-term effects of inflammation.
Medicine to treat SAIDs
- Anti-inflammatory drugs, NSAID pain relievers, or corticosteroids you take by mouth.
- Biologic treatments through a shot or IV.
An expert SAIDs team at UPMC
Having a group of many experts lets us provide thorough SAIDs care.
The team includes experts in:
- Rheumatic diseases, joint, bone, and connective tissue health.
- Immune disorders.
- Infectious diseases.
- Skin, digestive system, and kidney health issues.
- Mental health.
- Diet and nutrition.
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By UPMC Editorial Staff. Last reviewed on 2025-04-04.