Kevin C. Chan, PhD
The main objective is to identify the structural and functional brain connections that underlie the mechanisms of cross modal plasticity in aged and blind subjects using advanced, non-invasive magnetic resonance imaging techniques and the BrainPort® tactile-vision sensory substitution device.
Chao-Hsing Yeh, PhD, RN
The three specific aims of the study are to: assess the feasibility of recruiting chronic low back pain patients who are over 65 years of age to assess their adherence, the safety/tolerability and satisfaction with an auricular point acupressure intervention designed to reduce chronic low back pain; compare APA outcomes of pain intensity and physical function between two groups; and to explore potential physiological and psychological mediators that may contribute to pain relief resulting from APA.
Caterina Rosano, MD, PhD;
Howard Aizenstein, MD, PhD
The purpose is to quantify markers of vascularization and ultrastructure in relationship with mobility and cognition in LIFE-M participants at study entry and to compare markers of vascularization and ultrastructure in the group adhering to 2-years walking intervention as compared to the control group of stretching and toning.
Edward R. Burton, MD, DPhil, FRCP
The purpose of the study is to generate new models for identifying neuroprotective drugs for Parkinson's Disease and elucidating the role of aging in pathogenesis.
Pamela E. Toto, PhD, OTR.L, BCG, FAOTA
The purpose of the project is to evaluate the feasibility of instrumentation using Goal Attainment Scaling (GAS) with the medically complex client in a multi-disciplinary geriatrics care center and to identify themes emerging from the GAS process in relation to coordinated care planning.
Jennifer S. Brach, PhD, PT;
Pamela Peele, PhD;
Subashan Perera, PhD
The objectives of this study are to continue to build the research team to determine the feasibility of recruiting and retaining older adults into the study, to document variability of the outcomes of the Silver & Fit® intervention and to develop the system to obtain the necessary exercise adherence, healthcare utilization, and cost information.
Jennifer Hagerty Lingler, PhD, RN, FNP;
Scott Roberts, PhD;
Keith Johnson, MD;
Jason Karawish, MD;
Amanda Gentry, MPH, Project Director
The purpose of the project is to develop a standardized protocol for the disclosure of amyloid imaging results in the context of MCI using an iterative approach involving a panel comprised of local and external experts in neuroimaging, risk communication, regulatory affairs, and bioethics, and to establish the acceptability of an amyloid imaging results disclosure protocol among patients with mild cognitive impairment and their immediate family members.
Anna L. Marsland, PhD;
Peter J. Gianaros, PhD
The goal of the project is to collect pilot data examining whether peripheral inflammation in midlife is associated with white matter atrophy and microstructural alterations, which have been associated with cognitive aging.
Quasar Saleem Padiath, PhD
The purpose of the project is the generation and characterization of mice models for Autosomal Dominant Leukodystrophy.
Stasa Tadic, MD;
Neil Resnick, MD;
Werner Shaefer, MD;
Theodore Huppert, PhD;
Derek Griffiths, MD;
Becky Clarkson, PhD
The goal of the project is to assess whether functional near-infrared spectroscopy, fNIRS, can reliably record responses in the brain concordant with functional magnetic resonance imaging, FMRI, in areas known to be relevant for bladder function during filling of the bladder and urge sensation.
Fabrisia Ambrosio, PhD, MPT (PI)
The purpose of this pilot study is to investigate whether the application of an electrical stimulation (E-STIM) protocol in aged individuals promotes signaling pathways associated with activation of the myogenic program, while concomitantly inhibiting fibrogenic pathways.
Bret Goodpaster Ph.D.;
Dr. Paul Coen
The purpose of this study is to compare skeletal muscle and hepatic insulin sensitivity, fatty acid oxidation,and accumulation of intracellular lipid in young and old C57/BL6J mice., and to exampine the effect of three weeks of exercise on these factors.
Rebecca C. Thurston, PhD
The primary aim of this pilot study is to examine relationships between hot flashes, cardiac vagal control, and endothelial function
Steve Handler, MD, MS;
Richard D. Boyce, PhD;
Joseph Hanlon, PharmD, MS;
Roger Day, ScD;
Melissa I. Saul, MS
The objectives of this project are to:
Alfred L. Fisher, MD, PhD
The aims of this study are to:
Mark E. Wheeler, Ph.D.;
David A. Wolk, M.D.
The goal of the project is to study how age-related changes in memory performance are mediated by attentional control.
Howard B. Degenholtz, Ph.D.
The project will test the efficacy of a novel approach to improving quality of life of nursing home residents.
Laura J. Niedernhofer, M.D., Ph.D;
Paul D. Robbins, Ph.D.
This study aims to:
Etienne Sibille, Ph.D;
This proejct will estimate the influence of a common DNA polymorphism that affects 5‐HT1BR level, on the “molecular signature” of aging in the human postmortem brain.
Putative molecular mechanisms will then be investigated through biological pathwaybased bioinformatic analyses.
Based on the parallel analysis of two additional genes (Sirtuin 5, ortholog of known age-related genes and potential modulator of the Htr1b KO phenotype, and, Klotho, a “control” gene with characterized role in aging), a hypothetical mechanistic model will be formulated for the role of 5‐HT in brain aging, which in turn will lead subsequent research.