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UPMC Clinical Trials For Cardiac Care in South Central PA

Starts with Research leads to better care. The PinnacleHealth CardioVascular Institute’s ongoing commitment to research is key to our excellent outcomes, as we continue to expand our knowledge and skills.

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients with Severe Symptomatic Mitral Regurgitation (APOLLO)

Principal investigator(s): Hemal Gada, MD and Mubashir Mumtaz, MD

The trial is designed to evaluate the safety and efficacy of the Intrepid™ TMVR system in patients with severe, symptomatic mitral valve regurgitation. For more information, click here.

Research nurse contact at UPMC Pinnacle: hollisterr@upmc.edu

Annular Reduction for Transcatheter Treatment of Insufficient Mitral Valve (ACTIVE)

Principal investigator(s): Hemal Gada, MD and Mubashir Mumtaz, MD

The purpose of this study is to evaluate the safety and performance of the Edwards Cardioband™ Mitral Reconstruction System in adult patients with functional mitral regurgitation and heart failure who are not suitable candidates for traditional surgical mitral valve repair. This investigational device is inserted into the heart via a minimally invasive procedure using catheters in the groin. The randomized study compares mitral valve repair using the Edwards Cardioband System along with medical therapy compared to medical therapy alone. For more information, click here.

Research nurse contact at UPMC Pinnacle: hollisterr@upmc.edu

SPYRAL HTN-OFF MED Study

Principal investigator: William Bachinsky, MD

The purpose of this study is to obtain an assessment of the efficacy and safety of renal denervation in the absence of antihypertensive medications. For more information, click here.

Research nurse contact at UPMC Pinnacle: meisegc@upmc.edu

The ReCHORD™ Trial: Randomized Trial of the NeoChord™ DS1000™ System versus Open Surgical Repair

Principal Investigator: Mubashir Mumtaz, MD

The objective of this trial is to assess the safety and effectiveness of the study device in subjects with degenerative mitral valve disease receiving a mitral valve repair without cardiopulmonary bypass (treatment group) when compared to subjects receiving mitral valve repair using standard surgical techniques with cardiopulmonary bypass (control group). For more information, click here.

Research nurse contact at UPMC Pinnacle: hollisterr@upmc.edu

WaveCrest vs. Watchman Transseptal LAA Closure to Reduce AF-Mediated Stroke 2 (WAVECREST 2)

Principal Investigator: Chinmay Patel, MD

The trial is designed to demonstrate the safety and effectiveness of the Coherex WaveCrest Left Atrial Appendage (LAA) Occlusion System are non-inferior to the Watchman device. Patients enrolled in the study will be randomized in a 1:1 ratio to the treatment arm (Coherex WaveCrest LAA Occlusion System) or the control arm (Boston Scientific's Watchman LAA Occlusion system.) For more information, click here.

Research nurse contact at UPMC Pinnacle: hollisterr@upmc.edu

The ANTHEM-HFrEF Study

Principal investigator(s): Roberto Hodara, MD

The purpose of this study is to evaluate the Vitaria System in patients with heart failure and reduced ejection fraction (HFrEF). This study is a 2:1 randomized trial where patients receive Vitaria system implantation on the right cervical vagus nerve in addition to stable guideline-directed medical therapy or to continue receiving stable guideline-directed medical therapy alone (control arm). For more information, click here. NCT # 03425422

Research nurse contact at UPMC Pinnacle: toddag@upmc.edu

The CorCinch-HFrEF Study

Principal investigator(s): Hemal Gada, MD

Purpose: The purpose of this study is to evaluate the AccuCinch® Ventricular Repair System in patients with heart failure and reduced ejection fraction (HFrEF). This study is a non-randomized early feasibility study. For more information, click here. NCT # 03533517

Research nurse contact at UPMC Pinnacle: hollisterr@upmc.edu

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