From Cleveland area to UPMC Jameson
Take the Ohio Turnpike east to I-76 east to I-80 south to I-376 east. Take the exit marked Mitchell Road, New Castle. At the traffic light, turn right onto Route 18 south. This becomes Wilmington Avenue. Follow for approximately 4 miles. Turn right at the fifth traffic light, excluding the traffic light at Mitchell Road, onto Garfield Avenue and proceed to the hospital parking lot.
From Pittsburgh via I-79 North
Take Route I-79 north. Take exit 99 and turn left onto Route 422 west toward New Castle. Stay on business Route 422 west and not the bypass. Look for the Comfort Inn and Giant Eagle on the left. You will come to the intersection of Route 65. Epworth Church will be on the left and a gasoline station on the right. Continue straight and follow 422 west business signs. You will go through three traffic lights. At the third traffic light, you will see Cascade Galleria and Route 18 directly in front of you. Turn right onto Route 18 north. There are signs for UPMC Jameson-1 mile. Proceed through approximately seven traffic lights. Go up the hill, through the traffic light at the top of the hill and bear left at the Y in the road. At the second traffic light at Garfield Avenue, turn left and proceed to the hospital parking lot.
From Pittsburgh via I-376 West (old Route 60 north)
Take I-376 west to the Mitchell Road exit. At the traffic light, turn right onto Route 18 south. This becomes Wilmington Avenue. Follow for approximately four miles. Turn right at the 5th traffic light, excluding the traffic light at Mitchell Road, onto Garfield Avenue and proceed to the hospital parking lot. From north Route 18, Wilmington Road becomes Route 18 Wilmington Avenue.
From Slippery Rock
Take Route 108 West past Croton to East Washington Street. At that traffic light, turn right and stay in the center lane. At the 4th traffic light, the diamond with a statue and fountain will be on the left, Eckerd Drug Store will be ahead on the right, turn right onto Jefferson Street, Route 18 North. This becomes Wilmington Avenue. Proceed through approximately 3 traffic lights. Go up the hill, through the traffic light at the top of the hill and bear left at the “Y.” At the 2nd traffic light at Garfield Avenue, turn left and proceed to the hospital parking lot.
From Youngstown from Route 422
Go northeast on Market Street toward Wick Avenue by turning left. Market Street becomes Wick Avenue. Turn right onto US Route 422 East. Take the US Route 422 East ramp toward Campbell/New Castle. Merge onto US Route 422 East. Turn left onto PA Route 4004 PA Route 4004 becomes Pulaski Road. Pulaski Road becomes Wilmington Road, PA Route 18. Continue on PA Route 18 South to the next traffic light. Turn right at the traffic light at Garfield Avenue and proceed to the hospital parking lot.
From Youngstown from Boardman area via Route 224
From Ohio Route 7, turn right going east onto US Route 224. US Route 224 becomes US Route 224/PA Route 551. Stay straight on US Route 224 until you reach PA Route 18. Turn left onto PA Route 18. PA Route 18 becomes PA Route 18/Wilmington Avenue. Proceed up the hill to the traffic light, bear left at the “Y” and continue to the 2nd traffic light at Garfield Avenue. Turn left and proceed to the hospital parking lot.
From Meadville from Route 79 South or Route 80 West
Get off at the New Castle exit off Route 80 West onto Interstate 376 South Continue on Interstate 376 South to the Mitchell Road exit. At the traffic light, off the Mitchell Road exit, turn right onto Route 18 South. This becomes Wilmington Road. Follow for approximately 4 miles. Turn right at the 5th traffic light, excluding the traffic light at Mitchell Road, onto Garfield Avenue and proceed to the hospital parking lot. Note: From the North Route 18 Wilmington Road becomes Route 18 Wilmington Avenue.