Find a Doctor
Browse UPMC doctors and medical professionals to find the care that's right for you. Customize your search by specialty, zip code, last name, and more.
Visit the UPMC Find a Doctor website.
Cushing's disease is defined as a condition caused by chronic exposure to elevated levels of the hormone cortisol (hypercortisolism).
When a pituitary tumor is the cause of high cortisol, the disorder is called Cushing's disease.
At UPMC, the preferred Cushing’s disease treatment is to remove the pituitary tumor using the Endoscopic Endonasal Approach (EEA). This innovative, minimally invasive technique uses the nose and nasal cavities as natural corridors to access hard-to-reach or previously inoperable tumors. Benefits of EEA include:
As an additional treatment, your surgeon may recommend Gamma Knife® radiosurgery.
To make the diagnosis of Cushing's disease, your doctor will ask you about your symptoms and order diagnostic lab tests for cortisol.
Cushing's disease symptoms may include:
Diagnosing Cushing's disease requires laboratory studies demonstrating high levels of blood cortisol.
If tests show that cortisol levels are above normal, your doctor must identify the reason to determine the best treatment plan.
For most cases of Cushing’s disease, the best treatment is to remove the pituitary tumor that is causing the excessive levels of cortisol.
The pituitary tumor can be approached directly using the Endoscopic Endonasal Approach (EEA).
This state-of-the-art, minimally invasive approach allows surgeons to access the tumor through the natural corridor of the nose, without making an open incision. Surgeons then remove the pituitary tumor through the nose and nasal cavities.
EEA offers the benefits of no incisions to heal, no disfigurement, and a faster recovery time.
If you need complementary Cushing's disease treatments, such as radiation, those therapies can begin soon after EEA surgery.
Gamma Knife radiosurgery uses hundreds of highly focused radiation beams to target the pituitary tumor that's causing Cushing's disease, with no surgical incision.
For Cushing's disease, Gamma Knife treatment is used for residual pituitary tumor after surgery or elevated cortisol hormone levels despite surgery and medical management.
UPMC is the nation's leading provider of Gamma Knife procedures. Our treatments have proven effective for more than 12,000 people with tumors, vascular malformations, pain, and other functional problems.
Gamma Knife Radiosurgery
Dr. L. Dade Lunsford discusses Gamma Knife Radiosurgery.
Endoscopic Endonasal Approach (EEA)
Pituitary Tumor Removal Using the Endoscopic Endonasal Approach (EEA) at UPMC