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For more than 25 years, UPMC surgeons have been pioneering treatments and technology to access and remove tumors at the base of the skull, including the Endoscopic Endonasal Approach (EEA).
Because the base of the skull has proven to be one of the most challenging regions of the body to access, treatment options were once limited for patients with tumors or lesions in this area. However, with recent advancements and breakthroughs in treatment and surgery, patients with skull base tumors now have an array of surgical options that can help them return to leading a normal and active life.
The Endoscopic Endonasal Approach is an innovative surgical technique used to remove brain tumors and lesions—some as large as softballs—all through the nose. Our multidisciplinary team of neurosurgeons, otolaryngologists, ophthalmic surgeons, and spine surgeons have developed and refined this technique, and are among the most experienced in the world.
With EEA:
At UPMC, these surgeries are performed in dedicated, state-of-the-art suites that incorporate sophisticated imaging technology.
This minimally invasive approach uses the nose and sinuses as natural corridors to access tumors and lesions in critical areas at the base of the skull or top of the spine. The Endoscopic Endonasal Approach allows surgeons to treat many hard-to-reach tumors, even those once considered "inoperable," without disturbing the face or skull.
» Learn about the conditions treated with EEA
EEA offers patients a number of benefits that may improve their quality of life, including: no facial incisions or disfigurement, less trauma to the brain and critical nerves, fewer side effects, and shorter recovery times.
» Read more about EEA's benefits
The UPMC Center for Cranial Base Surgery performed its 5,000th EEA procedure in 2025. It was the first in the world to perform a number of procedures using this technique, and it is one of the busiest centers in the world for endoscopic treatment of pituitary tumors and tumors of the cranial base.
In addition to its successful use in adults, EEA has proven safe and effective in children. More than 100 children have been treated by UPMC surgeons using the Endoscopic Endonasal Approach—more than at any other neurosurgery center in the world.
» Read some of our EEA patient success stories
» Read clinical case studies
» Read common FAQs
» Read about EEA breakthroughs
As part of the University of Pittsburgh School of Medicine, the Department of Neurosurgery is committed to academic and research excellence, in addition to clinical excellence.
» Learn more about our education, research, and training opportunities
The Multidisciplinary Team of Distinction designation is based on meeting North American Skull Base Society (NASBS) membership criteria and may not be construed as a Medical Referral.
