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Depression in Late Life/Risk for Dementia 

Jordan Karp, MD, is professor of psychiatry, anesthesiology, and clinical and translational science at the University of Pittsburgh and UPMC Western Psychiatric Hospital. He is an internationally recognized expert in the field of geriatric psychiatry. Late-life depression may be brain “toxic.” This episode discusses geriatric depression and ongoing multisite PCORI/NIH geriatric research about a treatment-resistant depression (OPTIMUM/OPTIMUM-Neuro) trial. This comparative effectiveness research includes patient – cognition results and brain imaging.

Released: 5/23/19


  1.  Kok, RM and Reynolds, CF. Management of depression in older adults: A review. JAMA 2017 May: 317:20 2114-2122. 
  2.  Lenze, EJ, Voineskos, AN, Butters, MA, Karp, JF. Stopping cognitive decline in patients with Late-Life Depression: A new front in the fight against dementia. Am J Geriatr Psychiatry 2018 Aug: 26:8 828-834. DOI: 10.1016/j.jagp.2018.05.014

View the transcript for this podcast (PDF)