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Depression in Late Life/Risk for Dementia 

Jordan Karp, MD, is professor of Psychiatry, Anesthesiology, and Clinical and Translational Science at the University of Pittsburgh and UPMC Western Psychiatric Hospital. Late-life depression may be brain “toxic.” This episode discusses geriatric depression and ongoing multi-site PCORI/NIH geriatric research about a treatment-resistant depression (OPTIMUM/OPTIMUM-Neuro) trial. This comparative effectiveness research includes patients’ cognition and brain imaging. 

Released: 5/23/19


  1.  Kok, RM and Reynolds, CF. Management of depression in older adults: A review. JAMA 2017 May: 317:20 2114-2122. 
  2.  Lenze, EJ, Voineskos, AN, Butters, MA, Karp, JF. Stopping cognitive decline in patients with Late-Life Depression: A new front in the fight against dementia. Am J Geriatr Psychiatry 2018 Aug: 26:8 828-834. DOI: 10.1016/j.jagp.2018.05.014

View the transcript for this podcast (PDF)