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Mindfulness, Mood Lability, and The Brain in Youth at Risk: Neural and Behavioral Mechanisms

Dr. Danella Hafeman MD, PHD is Assistant Professor of Psychiatry at the University of Pittsburgh. She is the Principal Investigator of a NIMH Sponsored Clinical Trial titled “Neurobehavior Targets of Mindfulness in Youth at Risk for Mood-Disorders.” This podcast focuses on research methodology, manifestations, instruction and mindfulness interventions to reduce stress and mood lability among at risk middle school youth, thereby affecting key brain connectivity related to potential Bi-Polar outcomes among youth at risk.

Released: December 21, 2022


  1. Hafeman DM, Merranko J et al. Toward the Definition of a Bipolar Prodrome: Dimensional Predictors of Bipolar Spectrum Disorders in At-Risk Youths
  2. Hafeman DM, Ostroff AM et al. Mindfulness-based intervention to decrease mood lability in at-risk youth: Preliminary evidence for changes in resting state functional connectivity. J of Affective Disorders; 276; 23-29. July 2020