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Compression Therapy for Nonhealing Wounds

Nonhealing wounds, also called chronic wounds, can lead to further health complications and infections if not treated properly.

Compression therapy — which includes using compression bandages, stockings, wraps, and compression devices — can help nonhealing wounds close faster. The controlled pressure helps reduce swelling and encourage venous blood flow. This provides the right environment for a wound to heal.


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What Is Compression Therapy for Nonhealing Wounds?

Compression therapy is the application of therapeutic pressure to an extremity. The intentional pressure can come from a compression stocking, bandage, wrap, or device.

Compression therapy encourages venous blood flow, reduces edema (swelling), and improves lymphatic function, which drains excess fluid from tissues and returns it to the bloodstream.

Compression therapy has been known to help patients with nonhealing wounds by:

  • Decreasing their pain.
  • Decreasing their wound recovery time.
  • Improving their skin condition and irritation.
  • Reducing inflammation and wound fluid.
  • Reducing the chance that wounds return.

With the right pressure, techniques, and devices, compression therapy is a known effective treatment for multiple types of wounds.

Types of compression therapy

Depending on your type and severity of wound, you may be treated with:

Compression bandages

Compression bandages are usually meticulous, multilayered wraps around the affected area. They use a variety of materials and tension. The multiple layers create a gradual compression that is necessary to receive the healing benefits.

Most compression bandages are worn at all times. They allow for walking, as daily movement is encouraged to boost blood flow. Your care team may need to change your compression bandage during the week.

Compression bandages typically treat venous insufficiency. In venous insufficiency, blood pools in a lower extremity and other open wounds – most often in the legs – instead of getting back to the heart.

Compression devices

These machines look like inflatable sleeves for your extremities. When turned on, they inflate and deflate around your extremities, giving intermittent compressions. The pulsing sensations help move blood back to your heart.

This option requires you to be stationary during treatment, which can take 30 to 60 minutes, every day. Your doctor will discuss whether you need other treatment options alongside the compression device.

Compression stockings/wraps

Compression stockings may be leg-shaped or flat-knitted. One method includes a compression wrap worn underneath a compression stocking. Most compression stockings are designed so you can put them on and take them off yourself.

Depending on your doctor’s plan, you may need to keep the wrap and stocking on for days at a time. You may be able to take them off at certain times.

Compression stockings are specially fitted to your legs. Compression sleeves are specially fitted to your arms.

Conditions we treat with compression therapy

Compression therapy is known to be the most effective treatment for venous ulcers. These slow-to-heal wounds usually appear on the legs due to poor blood flow in the veins.

Venous ulcers are most commonly caused by venous insufficiency. This is a condition that prevents blood from returning to the heart.

Why Would I Need Compression Therapy?

Compression therapy is the standard treatment for venous ulcers. It can also significantly improve the condition of other types of ulcers.

If you are struggling with a wound that hasn’t closed in over six weeks and is caused by an impact on blood flow, compression therapy can help reduce inflammation and swelling and expedite healing so the wound can close.

How long does it take for a deep wound to heal?

Most deep wounds should heal within four to six weeks.  Wounds that don’t heal after six weeks may be chronic.

What could cause a wound not to heal?

A wound may not heal properly when the normal healing process gets stuck in the inflammatory stage and fails to progress.

Research shows this can happen when key immune cells, such as neutrophils and macrophages, do not reach the wound. This often occurs because an important regulator, FOXM1, is underactive.

This problem is common in chronic wounds like diabetic foot ulcers. It can lead to slow healing, infection risk, and further complications.

What Are the Risks and Complications of Compression Therapy?

While compression therapy is known to be relatively safe and effective, you may experience:

  • Allergic reaction to bandage materials.
  • Fungal or bacterial infection at the wound site.
  • Pain and discomfort.
  • Skin irritation.
  • Very rare complications of compression therapy include:
  • Arterial insufficiency (reduced blood flow to an artery).
  • Decompensated heart failure (decline in the heart’s ability to pump).
  • Nerve damage.
  • Soft tissue damage.

Talk with your health care provider about the risks and complications of compression therapy before beginning treatment if you are concerned.

What Should I Expect from Compression Therapy?

Before: How to prepare for compression therapy

Your care team will discuss the appropriate therapy for your condition.

Before any type of compression therapy is applied, you can expect your wound area to be cleaned and sterilized. You can also expect your doctor to inspect your wound, looking for any signs of infection or worsening condition.

Once the wound is disinfected and inspected, your care team will begin to apply the chosen type of compression therapy.

During your compression therapy

  • Compression bandages — If you are receiving compression bandaging, your care team will wrap the wound with multiple layers and tensions. They will explain the process to you, which may be uncomfortable at first. You can expect to wear your compression bandages at all times. Your care team will change them on a set schedule. You may need to wear a bandage cover when showering while undergoing compression bandage therapy.
  • Compression devices — If you are receiving compression therapy from a device, you can expect to be in the machine for up to an hour at a time. Depending on your condition, you may also require another type of compression therapy. Compression machines are typically scheduled daily until the wound begins to heal. They continue afterward to prevent the wound from returning.
  • Compression stockings/wraps — If you are receiving compression stockings or wraps, your doctor may fit them to your leg and wrap the wound in layers. Depending on the condition and severity of your wound, you may be able to redress your compression wrap and take your compression stockings off and on yourself. Your care team will provide full instructions.

Recovery after compression therapy

Even after a wound finally heals, it’s important to follow healthy guidelines to prevent new wounds from opening.

Some tips for staying healthy and wound-free include:

  • Consider your footwear and clothing — Ill-fitting or tight clothing and shoes can put unnecessary pressure on areas that are prone to ulcers. Wear well-fitting, comfortable clothes that do not strain your legs.
  • Follow wound care instructions — You may need to use a plastic cover to shower with your compression bandage. Make sure to check for leaking fluid or other signs that the wound is not healing properly.
  • Maintain a healthy weight — Weight can affect the body’s likelihood of getting an ulcer and can make healing take longer. If you are overweight, talk to your doctor about ways to lose weight and maintain healthy habits.
  • Mindfulness — Wearing compression bandages or stockings can feel annoying, itchy, or uncomfortable at first. Practice mindfulness techniques and take care of your mental health. The more you take care of your mind, the easier your wound care will become!
  • Reduce alcohol and cigarette intake — Drinking and smoking can reduce blood flow, interfere with tissue repair, and weaken the immune system. Consider quitting to enhance overall health.
  • Regular movement — Walking can be a great exercise option that keeps the body moving and blood flowing. Ankle circles, calf pumps, and other leg movements are also beneficial additions to your daily routine.

When should I call my doctor about compression therapy complications?

Compression therapy is a safe and well-known therapy for ulcers and other wounds. However, it's important to call your doctor if you are experiencing:

  • Blue-colored or pale toes.
  • Excess swelling in the legs and feet.
  • Feeling generally unwell or experiencing increased pain from the wound site.
  • Increased discharge from the wound site.
  • Increase in shortness of breath.
  • Numbness, tingling, or loss of sensation in your feet or toes.
  • Unusual or increasing pain in the legs, feet, or toes.

By UPMC Editorial Staff. Last reviewed on 2026-05-18.

Additional Information
  • All about compression: What is compression therapy and how can it help you? Molnlycke.
  • Treatment: Venous leg ulcer. NHS.
  • Leg ulceration in venous and arteriovenous insufficiency assessment and management with compression therapy as part of a holistic wound‑healing strategy. Journal of Wound Care.
  • Use of compression therapy to treat lower limb wounds across Europe: a scoping review protocol. PubMed.
  • Cell-free therapeutics for non-healing wounds: role of MSC-derived exosomes in macrophage polarization, angiogenesis, and fibroblast-mediated ECM remodeling-bridging preclinical insights to clinical translation. PubMed.
  • How Compression Therapy Enhances Wound Healing. The Wound Pros.
  • The Expert's Guide to Treating Non-Healing Wounds. Wound Treatment.
  • Risks and contraindications of medical compression treatment – A critical reappraisal. An international consensus statement. PubMed Central.
  • Researchers Uncover Clues to Why Some Wounds Don’t Heal: Innovative research made possible by prestigious NIH Bench-to-Bedside and Back Program Award. NIH.
  • Wound Healing Phases. NIH.
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