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Breast Cancer Associated with Pregnancy

Breast cancer can occur at any time, including during pregnancy. It's the most common form of cancer in pregnancy, affecting approximately one in 3,000 women.

Although pregnancy itself does not cause breast cancer and breast cancer itself does not harm the developing fetus, it requires specialized treatment. At UPMC, our experts offer a full range of treatment options and will develop a personalized plan to reduce risks for both mother and baby.

Looking for Breast Cancer Associated with Pregnancy Care?

Related services include:

  • Breast cancer.
  • Breast health.
  • Women's health.

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On this page

  • What Is Breast Cancer Associated with Pregnancy?
  • What Are the Symptoms of Breast Cancer Associated with Pregnancy?
  • How Do You Diagnose Breast Cancer Associated with Pregnancy?
  • How Do You Treat Breast Cancer Associated with Pregnancy?

What Is Breast Cancer Associated with Pregnancy?

Breast cancer occurs when cells in your breast multiply and grow out of control, forming a tumor that can spread to surrounding tissues or other areas of your body. Breast cancer can occur at any time, including during pregnancy.

What happens if you have breast cancer when you are pregnant?

Breast cancer treatment during pregnancy is possible. However, some treatment options — such as radiation therapy, hormone therapy, targeted therapy, and immunotherapy — are not recommended during pregnancy due to the risk of harm to your unborn baby.

Your doctor will discuss the risks and benefits of each treatment option with you and develop a personalized treatment plan based on your needs and preferences.

Your breast cancer care team will work with maternal-fetal medicine experts to reduce treatment-associated risks for you and your unborn baby.

What are the types of breast cancer associated with pregnancy? 

Any type of breast cancer can occur during pregnancy, including:

  • Angiosarcoma — Starts in the cells that line your blood or lymph vessels.
  • Ductal carcinoma in situ (DCIS) — An early-stage breast cancer that develops in the lining of the milk ducts and has not spread to other parts of your body.
  • Inflammatory breast cancer — A rare, aggressive type of breast cancer that causes reddening and swelling of your breast.
  • Invasive ductal carcinoma — The most common type of breast cancer, invasive ductal carcinoma starts in the lining of your milk ducts and may be preceded by ductal carcinoma in situ.
  • Invasive lobular carcinoma — The second most common type of breast cancer, it begins in the glands that produce milk.
  • Lobular carcinoma in situ (LCIS) — Starts in the glands that produce milk, called the lobules, and has not spread to other parts of your body. Although not technically considered cancer, LCIS increases your risk of developing breast cancer in the future.
  • Paget’s disease of the nipple — Causes redness and irritation of the nipple on one breast. It can be mistaken for eczema or an infection.
  • Phyllodes tumor — A rare tumor that develops in the connective tissue of your breast.

How common is pregnancy-associated breast cancer?

Breast cancer is the most common form of cancer in pregnancy, affecting approximately one in 3,000 women.

What causes breast cancer associated with pregnancy?

Pregnancy itself does not cause breast cancer. Breast cancer occurs when cells in your breast multiply and grow out of control, forming a tumor that can spread to surrounding tissues or other areas of your body.

What are the risk factors and complications of breast cancer associated with pregnancy?

Breast cancer during pregnancy risk factors

Pregnancy is associated with a specific set of risks for breast cancer, including:

  • Family history of breast cancer.
  • Family history of late menopause.
  • First menarche (menstruation) before age 12.
  • First pregnancy after age 30.
  • Previous pregnancies not followed by breastfeeding.

Complications of breast cancer associated with pregnancy

Due to changing hormones during pregnancy, breast cancer is often diagnosed at a later stage in pregnant women. A later diagnosis can allow breast cancer to spread to other areas of the body, making it more challenging to treat.

Breast cancer treatment during pregnancy is possible, but it's more complex due to the possible effects on the developing baby.

How can I prevent breast cancer during pregnancy? 

There is nothing you can do to prevent breast cancer during pregnancy. Although routine breast cancer screening with mammography is considered safe during pregnancy, women who are not eligible for routine screening should perform monthly breast self-exams to increase the chances of identifying symptoms early.

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What Are the Signs and Symptoms of Breast Cancer During Pregnancy?

Symptoms of breast cancer during pregnancy include:

  • A change in the size or shape of your chest.
  • A dimpled, puckered, or "orange-peel" appearance of your skin.
  • A lump or thickening on your chest or under your arm, which could be painless, firm, or fixed.
  • A nipple that retracts (turns inward).
  • Discharge of blood or any fluid other than breast milk from your nipple.
  • Red or swollen skin on your chest, nipple, or areola (the dark circle of skin around your nipple).

When should I see a doctor about my breast cancer symptoms during pregnancy?

If you notice symptoms of breast cancer, you should schedule an appointment with your doctor right away.

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How Do You Diagnose Breast Cancer During Pregnancy?

To diagnose breast cancer associated with pregnancy, your doctor will ask about your symptoms, perform a physical exam, and order imaging tests.

What to expect during your visit

If your doctor suspects breast cancer, they will:

  • Ask about your symptoms.
  • Ask about family history of breast cancer.
  • Perform a physical exam.
  • Order imaging tests.
  • Review your health history and medications.

Tests to diagnose breast cancer associated with pregnancy

Your doctor may order diagnostic imaging studies, including:

  • 3D mammogram (tomosynthesis) — A safe, noninvasive x-ray of your breast tissue. Your doctor may use computer-aided detection (CAD) software, which highlights abnormalities in your breast tissue.
  • Magnetic resonance imaging (MRI) — A safe, non-invasive imaging test that uses a magnetic field and radio waves to produce highly detailed images of breast tissue without radiation exposure.
  • Ultrasound (sonography) — A painless, noninvasive test that uses high-frequency sound waves to produce real-time pictures of your breast tissue.

Because mammography uses only a small amount of radiation, it is considered safe during pregnancy. However, your doctor may recommend MRI or ultrasound imaging as an alternative diagnostic imaging technique to reduce radiation exposure to your developing baby.

Your doctor may also order a minimally invasive breast biopsy, which involves using a hollow needle to take a sample of breast tissue to be tested for cancer. Your doctor will perform the biopsy using mammography, MRI, or ultrasound guidance and local anesthesia to numb the treatment area, which is considered safe during pregnancy.

Breast cancer associated with pregnancy prognosis

Early diagnosis of breast cancer during pregnancy improves the chances of successful treatment. However, it is often diagnosed in its later stages due to changing hormone levels.

Your prognosis after a breast cancer diagnosis will depend on your overall health, as well as the type and stage of your breast cancer. Your doctor will discuss your expected prognosis with you.

What is the survival rate for breast cancer in pregnancy?

Survival rates for breast cancer in pregnancy depend on the type and stage of the cancer. According to the American Cancer Society, most studies have shown that outcomes for pregnant and nonpregnant women diagnosed with the same type and stage of breast cancer are the same.

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How Do You Treat Breast Cancer Associated with Pregnancy?

The goals of breast cancer treatment are to remove the tumor, reduce the risk that the cancer will spread to other parts of your body, and lower the chances of recurrence after treatment.

Your care team will develop a personalized treatment plan based on:

  • Your physical and emotional health.
  • The health of your developing baby.
  • The results of your tests.
  • The stage of your pregnancy.

Your doctor will discuss the risks and benefits of each treatment, which may include:

Surgery for breast cancer associated with pregnancy

Surgery is often the primary treatment for breast cancer and is considered safe during pregnancy.

If you are diagnosed with breast cancer, your doctor may recommend:

  • Lumpectomy — Also known as breast-conserving surgery or a partial mastectomy, a lumpectomy is a surgical procedure to remove the part of your breast with a cancerous tumor and some healthy surrounding tissue.
  • Mastectomy — A surgical procedure to remove the entire breast. When both breasts are removed, it is known as a double mastectomy.

Your doctor may recommend surgery to remove and test your lymph nodes to determine whether your breast cancer has spread.

Lymph node procedures include:

  • Sentinel lymph node biopsy — A minimally invasive procedure to remove the sentinel (main) lymph node in the axilla (armpit) to test it for cancer. It is performed to determine if cancer has spread to your lymph nodes.
  • Axillary lymph node dissection — Surgery to remove all or some of the axillary nodes, a group of lymph nodes in the armpit, if your sentinel lymph node biopsy is positive for cancer.

Anesthesia during pregnancy

Anesthesia — the medication used to make you sleep during surgery — is generally considered safe during pregnancy. If your doctor recommends breast cancer surgery during pregnancy, your surgeon, anesthesiologist, and a high-risk obstetrician will work together to develop an anesthesia plan that minimizes risk for you and your baby.

Medical oncology for breast cancer associated with pregnancy

Medical oncology for breast cancer involves using different types of anticancer medications to slow or stop breast cancer growth. It can be administered before or after surgery, or as a long-term treatment to reduce the risk of cancer recurrence.

Chemotherapy — which uses medications that travel through your bloodstream to kill cancer cells throughout your body — is considered safe during your second or third trimester. It is not safe during your first trimester.

Hormone therapy, immunotherapy, and targeted therapy are not recommended during pregnancy due to potential risks to your unborn baby.

Radiation oncology for breast cancer associated with pregnancy

Radiation oncology is a medical specialty that uses radiation therapy to kill cancer cells. Because radiation therapy for breast cancer involves using high-energy x-rays to precisely target your tumor, it is not recommended for pregnant women due to the risk of harm to the fetus from radiation exposure.

Why choose UPMC for breast cancer care during pregnancy?

When you choose UPMC for breast cancer care during pregnancy, you will receive:

  • Comprehensive breast cancer expertise — The breast cancer experts at UPMC provide state-of-the-art care for every form of breast cancer at every stage of the disease.
  • Personalized, collaborative care — Our surgical, medical, and radiation oncologists work together with high-risk obstetricians to plan the best course of therapy for you.
  • Supportive services tailored to your needs — Our approach to breast cancer care honors your preferences by blending advanced clinical methods with supportive services for the best possible results.

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By UPMC Editorial Staff. Last reviewed on 2025-09-18.

  • American Cancer Society. Treating Breast Cancer During Pregnancy.
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