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Primary Sclerosing Cholangitis (PSC)

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The hepatologists at the UPMC Center for Liver Diseases provide care for primary sclerosing cholangitis (PSC), a disease that causes the bile ducts within your liver to become chronically inflamed and leads to scarring and blockages.  As those bile ducts become compromised, your liver function is affected. The resulting liver damage can lead to cirrhosis, or even the need for a liver transplant.

PSC is frequently associated with inflammatory bowel disease, specifically ulcerative colitis. Symptoms may include:

  • Abdominal pain
  • Unexplained weight loss
  • Jaundice (yellowing of the skin or eyes)
  • Fatigue
  • Chills
  • Extreme itching

PSC is diagnosed by routine blood work revealing elevated liver enzyme levels. Most patients are asymptomatic in the early stages, but individuals experiencing symptoms should contact their physician for evaluation.

The cause of PSC is unknown and liver transplant is the only known cure. Medical management and surgical intervention can reduce symptoms and delay further liver damage.

To learn more about PSC and the specialized treatment available at the UPMC Center for Liver Diseases, or to schedule an appointment, call 412-647-1170.