Regenerative medicine uses clinical procedures to repair or replace damaged or diseased tissues and organs, versus some traditional therapies that just treat symptoms.
To realize the vast potential of tissue engineering and other techniques aimed at repairing damaged or diseased tissues and organs, the University of Pittsburgh School of Medicine and UPMC established the McGowan Institute for Regenerative Medicine. The McGowan Institute serves as a single base of operations for the University’s leading scientists and clinical faculty working to develop tissue engineering, cellular therapies, and artificial and biohybrid organ devices.
The McGowan Institute is the most ambitious regenerative program in the nation, coupling biology, clinical science, and engineering. Success in our mission will impact patients’ lives, bring economic benefit, serve to train the next generation of researchers, and advance the expertise of our faculty in the basic sciences, engineering, and clinical sciences. Our efforts proudly build upon the pioneering achievements of the Thomas E. Starzl Transplantation Institute.
While there are certain select therapies based on regenerative medicine principles now in clinical use, much work lies ahead to realize the potential of this growing field. Advances in the underlying science, engineering strategies to harness this science, and successful commercial activities are all required to bring new therapies to patients.
McGowan Institute for Regenerative Medicine
450 Technology Drive
Pittsburgh, PA 15219
The McGowan Institute sponsors a podcast series on regenerative medicine. Listen to some of the world's leading regenerative medicine researchers and physicians talk about their work.
The 2021 International Space Station Research and Development Conference (ISSRDC) featured a fireside chat on biomanufacturing in space. Gary Rodrigue, MBA, director of programs and partnerships at the Center for the Advancement of Science in Space (CASIS), moderated a discussion with William Wagner, PhD, director of the University of Pittsburgh’s McGowan Institute for Regenerative Medicine. The discussion focused on the value of space-based biomanufacturing and the critical role of the orbiting laboratory in advancing this research area.
McGowan Institute for Regenerative Medicine faculty member J. Peter Rubin, MD, FACS, Chair of the Department of Plastic Surgery, the UPMC Endowed Professor of Plastic Surgery, Director of UPMC Wound Healing Services, and Professor of Bioengineering at the University of Pittsburgh, was recently interviewed by Olga Villaverde, the host of Dr. Q&A of AllHealthTV.com. Dr. Rubin answered many medical questions from Ms. Villaverde and viewers.
It was a nagging mystery: A rare-disease expert at UPMC Children’s Hospital of Pittsburgh had found a successful treatment for two of the deadliest symptoms of one of the more common classes of rare diseases diagnosed by newborn screenings, but one symptom—painful episodes of muscle breakdown that land victims in intensive care—persisted. The scientists’ paper in the journal Clinical & Translational Immunology announced that they’ve gotten to the bottom of the self-destructive syndrome and have a good lead on a treatment.
Childbirth is a momentous and fraught time. For women, childbirth is one of the most significant biomechanical events in life – in terms of forces and motion, the body during childbirth is a structure stressed to extremes. For bioengineer Steven Abramowitch, PhD, that is not a cold description. He studies damage to women’s pelvises due to pregnancy and delivery – damage that may only manifest decades after the birth. His team relies on resources in modeling structures of the pelvis that indicate potential health problems. His work includes support from McGowan Institute for Regenerative Medicine affiliated faculty member Pamela Moalli, MD, PhD.