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The McGowan Institute for Regenerative Medicine

Merging Science with Technology to Treat Disease

Regenerative medicine uses clinical procedures to repair or replace damaged or diseased tissues and organs, versus some traditional therapies that just treat symptoms.

To realize the vast potential of tissue engineering and other techniques aimed at repairing damaged or diseased tissues and organs, the University of Pittsburgh School of Medicine and UPMC established the McGowan Institute for Regenerative Medicine. The McGowan Institute serves as a single base of operations for the University’s leading scientists and clinical faculty working to develop tissue engineering, cellular therapies, and artificial and biohybrid organ devices.

The McGowan Institute is the most ambitious regenerative program in the nation, coupling biology, clinical science, and engineering. Success in our mission will impact patients’ lives, bring economic benefit, serve to train the next generation of researchers, and advance the expertise of our faculty in the basic sciences, engineering, and clinical sciences. Our efforts proudly build upon the pioneering achievements of the Thomas E. Starzl Transplantation Institute.

While there are certain select therapies based on regenerative medicine principles now in clinical use, much work lies ahead to realize the potential of this growing field. Advances in the underlying science, engineering strategies to harness this science, and successful commercial activities are all required to bring new therapies to patients.

Regenerative Medicine Podcasts

The McGowan Institute sponsors a podcast series on regenerative medicine. Listen to some of the world's leading regenerative medicine researchers and physicians talk about their work.

Listen to the most recent podcasts.

News and Events

Video: “Hope vs. Hype of Stem Cell Therapy”

This first-ever open-to-the-public session of the annual scientific retreat was organized by McGowan Institute for Regenerative Medicine faculty members based on general questions they receive from the public almost on a daily basis.  The purpose of the event is to provide an honest discussion with stem cell therapy and science communication experts on what is hope, what is hype, what is experimental, and what is therapeutic relative to various advertisements and promises regarding stem cells.  The program’s conversation aims to sort out the alternative facts and the fake news surrounding the medical science of stem cells.  Many factors determine the safety and efficacy of stem cell treatments.  Simply put, you need the right cells, to the right patient, at the right time, in the right way. If scientists do not ensure the field of stem cells research is credible through good science and ethical practice, the field will quickly become unbelievable.

The Matrix

The Badylak Lab was featured recently on the weekly TV news show, Full Measure.  McGowan Institute for Regenerative Medicine deputy director Stephen Badylak, DVM, PhD, MD, Professor in the Department of Surgery at the University of Pittsburgh and Director of the Center for Pre-Clinical Tissue Engineering within the McGowan Institute, was interviewed by Joce Sterman, an investigative journalist whose work has won her numerous awards including regional Emmys, Associated Press recognition, and an Edward R. Murrow award for investigative contributions to breaking news.

Changing Frequencies: Pitt Bioengineers Look Deeper into How Electrical Stimulation Activates Neurons

Electrical stimulation of the brain is common practice in neuroscience research and is an increasingly common and effective clinical therapy for a variety of neurological disorders. However, there is limited understanding of why this treatment works at the neural level.  A paper published by McGowan Institute for Regenerative Medicine affiliated faculty member Takashi Kozai, PhD, assistant professor of bioengineering at the University of Pittsburgh Swanson School of Engineering, addresses gaps in knowledge over the activation and inactivation of neural elements that affect the desired responses to neuromodulation.

Technology Developed in Brown and Cheetham Laboratories Receives $2.4 Million DoD Award to Advance Its Peripheral Nerve Matrix Technology to the Clinic

Peripheral nerve matrix (PNM) is an injectable gel derived from porcine tissue that promotes and supports repair and regeneration in injured peripheral nerves. PNM technology is based on 4 years of research in the laboratory of McGowan Institute for Regenerative Medicine faculty member Bryan Brown, PhD and the laboratory of McGowan Institute affiliated faculty member Jonathan Cheetham, VetMB, Diplomate ACVS, PhD.

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